The Dynamics of GABA Signaling: Revelations from the Circadian Pacemaker in the Suprachiasmatic Nucleus

Highlights • Synaptic and non-synaptic release of GABA occurs in the suprachiasmatic nucleus. • GABAA -PHASIC and GABAA -TONIC receptors are active in the suprachiasmatic nucleus. • GABA has inhibitory and excitatory actions on suprachiasmatic neurons. • GABAA and GABAB receptors modulate the phase...

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Veröffentlicht in:	Frontiers in neuroendocrinology 2017-01, Vol.44, p.35-82
Hauptverfasser:	Elliott Albers, H, Walton, James C, Gamble, Karen L, McNeill, John K, Hummer, Daniel L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzodiazepines Biological Clocks - physiology Cation chloride cotransporters Circadian Rhythm - physiology Endocrinology & Metabolism Entrainment Ethanol GABA vesicular transporters GABAA receptors GABAB receptors gamma-Aminobutyric Acid - physiology Glutamic acid decarboxylase Humans Membrane GABA transporters Neurosteroids Signal Transduction - physiology Suprachiasmatic Nucleus - physiology
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Beschreibung
Zusammenfassung:	Highlights • Synaptic and non-synaptic release of GABA occurs in the suprachiasmatic nucleus. • GABAA -PHASIC and GABAA -TONIC receptors are active in the suprachiasmatic nucleus. • GABA has inhibitory and excitatory actions on suprachiasmatic neurons. • GABAA and GABAB receptors modulate the phase of the circadian pacemaker. • GABA can both inhibit and mediate the effects of light on the circadian pacemaker.
ISSN:	0091-3022 1095-6808
DOI:	10.1016/j.yfrne.2016.11.003