Transfer of convalescent serum to pregnant mice prevents Zika virus infection and microcephaly in offspring

Zika virus （ZIKV） is spreading rapidly around the world in over 60 countries. There is a mounting concern over the association of ZIKV infection and devastating cases of fetal and newborn microcephaly cases [1]. The connection between ZIKV infection and microcephaly was first proposed based on the p...

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Veröffentlicht in:	Cell research 2017-01, Vol.27 (1), p.158-160
Hauptverfasser:	Wang, Shuo, Hong, Shuai, Deng, Yong-Qiang, Ye, Qing, Zhao, Ling-Zhai, Zhang, Fu-Chun, Qin, Cheng-Feng, Xu, Zhiheng
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/1933 631/250/255/2514 692/617/375/2764 692/700/565/1331 Animals Biomedical and Life Sciences Cell Biology Disease Models, Animal Embryo, Mammalian - pathology Embryo, Mammalian - virology Female Letter to the Editor Life Sciences Mice Microcephaly - prevention & control Microcephaly - virology Offspring Pregnancy Serum - metabolism Vector-borne diseases Viral Vaccines - immunology Zika Virus - immunology Zika Virus Infection - prevention & control 后代怀孕恢复期畸形病毒感染老鼠胎脑组织血清
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Beschreibung
Zusammenfassung:	Zika virus （ZIKV） is spreading rapidly around the world in over 60 countries. There is a mounting concern over the association of ZIKV infection and devastating cases of fetal and newborn microcephaly cases [1]. The connection between ZIKV infection and microcephaly was first proposed based on the presence of ZIKV in microcephalic fetal brain tissues .
ISSN:	1001-0602 1748-7838
DOI:	10.1038/cr.2016.144