The effects of tumor treating fields and temozolomide in MGMT expressing and non-expressing patient-derived glioblastoma cells

Highlights • Tumor treating fields (TTFs) & temozolomide (TMZ) in TMZ resistant & sensitive cells. • All cell lines were equally sensitive to the inhibitory effects of TTFs. • Inhibitory effect of TTFs was independent of TMZ and did not overcome TMZ resistance. • The optimum frequency for TT...

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Veröffentlicht in:	Journal of clinical neuroscience 2017-02, Vol.36, p.120-124
Hauptverfasser:	Clark, Paul A, Gaal, Jordan T, Strebe, Joslyn K, Pasch, Cheri A, Deming, Dustin A, Kuo, John S, Robins, H. Ian
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Alkylating - pharmacology Cancer stem cells Cell Line, Tumor Cell Proliferation - drug effects Cell Proliferation - radiation effects Cell Survival - drug effects Cell Survival - radiation effects Cells, Cultured Dacarbazine - analogs & derivatives Dacarbazine - pharmacology DNA Modification Methylases - genetics DNA Modification Methylases - metabolism DNA Repair Enzymes - genetics DNA Repair Enzymes - metabolism Electromagnetic Fields Glioblastoma Glioblastoma - genetics Glioblastoma - metabolism Humans MGMT methylation Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - radiation effects Neurology Neurons - drug effects Neurons - radiation effects Temozolomide Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Tumor treating fields
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Zusammenfassung:	Highlights • Tumor treating fields (TTFs) & temozolomide (TMZ) in TMZ resistant & sensitive cells. • All cell lines were equally sensitive to the inhibitory effects of TTFs. • Inhibitory effect of TTFs was independent of TMZ and did not overcome TMZ resistance. • The optimum frequency for TTFs (200 kHz) was the same frequency used clinically.
ISSN:	0967-5868 1532-2653
DOI:	10.1016/j.jocn.2016.10.042