Benefits and Risks of Antiretroviral Therapy for Perinatal HIV Prevention

In this randomized, controlled trial in Africa and India, combination antiretroviral therapy was more effective than standard therapy in preventing mother-to-child transmission of HIV but was associated with increased toxic effects. Antiretroviral regimens used for the prevention of mother-to-child...

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Veröffentlicht in:The New England journal of medicine 2016-11, Vol.375 (18), p.1726-1737
Hauptverfasser: Fowler, Mary G, Qin, Min, Fiscus, Susan A, Currier, Judith S, Flynn, Patricia M, Chipato, Tsungai, McIntyre, James, Gnanashanmugam, Devasena, Siberry, George K, Coletti, Anne S, Taha, Taha E, Klingman, Karin L, Martinson, Francis E, Owor, Maxensia, Violari, Avy, Moodley, Dhayendre, Theron, Gerhard B, Bhosale, Ramesh, Bobat, Raziya, Chi, Benjamin H, Strehlau, Renate, Mlay, Pendo, Loftis, Amy J, Browning, Renee, Fenton, Terence, Purdue, Lynette, Basar, Michael, Shapiro, David E, Mofenson, Lynne M
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Sprache:eng
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Zusammenfassung:In this randomized, controlled trial in Africa and India, combination antiretroviral therapy was more effective than standard therapy in preventing mother-to-child transmission of HIV but was associated with increased toxic effects. Antiretroviral regimens used for the prevention of mother-to-child transmission of the human immunodeficiency virus (HIV) have evolved from the first successful trial that used zidovudine single-drug prophylaxis in 1994 to current triple-drug regimens. 1 , 2 Although there are clear benefits of combination antiretroviral therapy (ART) for the mother and infant, these do not come without risks; some studies have shown higher rates of adverse pregnancy outcomes with maternal ART than with regimens containing fewer antiretroviral agents. 3 – 5 The Promoting Maternal and Infant Survival Everywhere (PROMISE) trial compared the relative efficacy and safety of various proven antiretroviral strategies for the prevention of . . .
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMoa1511691