Elementary immunology: Na+ as a regulator of immunity

The skin can serve as an interstitial Na + reservoir. Local tissue Na + accumulation increases with age, inflammation and infection. This increased local Na + availability favors pro-inflammatory immune cell function and dampens their anti-inflammatory capacity. In this review, we summarize available data on how NaCl affects various immune cells. We particularly focus on how salt promotes pro-inflammatory macrophage and T cell function and simultaneously curtails their regulatory and anti-inflammatory potential. Overall, these findings demonstrate that local Na + availability is a promising novel regulator of immunity. Hence, the modulation of tissue Na + levels bears broad therapeutic potential: increasing local Na + availability may help in treating infections, while lowering tissue Na + levels may be used to treat, for example, autoimmune and cardiovascular diseases.