Associations of childhood adversity and adulthood trauma with C-reactive protein: A cross-sectional population-based study

Highlights • High prevalence of trauma exposure in population-based sample. • Independent association of childhood adversity and elevated inflammation in old age. • Independent association of adulthood trauma and elevated inflammation in old age. • No interaction of childhood adversity and adulthood...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2016-03, Vol.53, p.105-112
Hauptverfasser:	Lin, Joy E, Neylan, Thomas C, Epel, Elissa, O’Donovan, Aoife
Format:	Artikel
Sprache:	eng
Schlagworte:	Adulthood trauma Aged Allergy and Immunology Biomarkers - blood C-reactive protein C-Reactive Protein - metabolism Childhood adversity Cross-Sectional Studies Female Humans Immune system Inflammation Inflammation - blood Inflammation - epidemiology Longitudinal Studies Male Mental Disorders - blood Mental Disorders - epidemiology Middle Aged Prevalence Psychiatry Risk Factors Socioeconomic Factors Stress, Psychological - blood Stress, Psychological - epidemiology Trauma and Stressor Related Disorders - blood Trauma and Stressor Related Disorders - epidemiology United States - epidemiology
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Beschreibung
Zusammenfassung:	Highlights • High prevalence of trauma exposure in population-based sample. • Independent association of childhood adversity and elevated inflammation in old age. • Independent association of adulthood trauma and elevated inflammation in old age. • No interaction of childhood adversity and adulthood trauma with inflammation. • Inflammation may mediate relationship between trauma exposure and ill health.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2015.11.015