Metal-free 18F-labeling of aryl-CF2H via nucleophilic radiofluorination and oxidative C-H activation

Metal-free 18F-labeling of aryl-CF2H via nucleophilic radiofluorination and oxidative C-H activation

A metal-free and selective method to form [18F]aryl-CF2H through nucleophilic radiofluorination of benzyl (pseudo)halides and oxidative C-H activation of benzylic C-H bonds has been developed. The method is operationally simple and tolerates a variety of electron-neutral/deficient arenes and heteroa...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2016-12, Vol.53 (1), p.126-129
Hauptverfasser: Yuan, Gengyang, Wang, Feng, Stephenson, Nickeisha A, Wang, Lu, Rotstein, Benjamin H, Vasdev, Neil, Tang, Pingping, Liang, Steven H
Format: Artikel
Sprache:eng
Schlagworte:
Activation
Aromatic compounds
Chemical bonds
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Beschreibung
Zusammenfassung:A metal-free and selective method to form [18F]aryl-CF2H through nucleophilic radiofluorination of benzyl (pseudo)halides and oxidative C-H activation of benzylic C-H bonds has been developed. The method is operationally simple and tolerates a variety of electron-neutral/deficient arenes and heteroarenes.
ISSN:1359-7345
1364-548X
DOI:10.1039/c6cc07913j