Is There a Dose-Response Relationship for Heart Disease With Low-Dose Radiation Therapy?
Purpose To quantify cardiac radiation therapy (RT) exposure using sensitive measures of cardiac dysfunction; and to correlate dysfunction with heart doses, in the setting of adjuvant RT for left-sided breast cancer. Methods and Materials On a randomized trial, 32 women with node-positive left-sided...
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| creator | Chung, Eugene, MD, PhD, JD Corbett, James R., MD Moran, Jean M., PhD Griffith, Kent A., MS Marsh, Robin B., CMD Feng, Mary, MD Jagsi, Reshma, MD, DPhil Kessler, Marc L., PhD Ficaro, Edward C., PhD Pierce, Lori J., MD |
| description | Purpose To quantify cardiac radiation therapy (RT) exposure using sensitive measures of cardiac dysfunction; and to correlate dysfunction with heart doses, in the setting of adjuvant RT for left-sided breast cancer. Methods and Materials On a randomized trial, 32 women with node-positive left-sided breast cancer underwent pre-RT stress single photon emission computed tomography (SPECT-CT) myocardial perfusion scans. Patients received RT to the breast/chest wall and regional lymph nodes to doses of 50 to 52.2 Gy. Repeat SPECT-CT scans were performed 1 year after RT. Perfusion defects (PD), summed stress defects scores (SSS), and ejection fractions (EF) were evaluated. Doses to the heart and coronary arteries were quantified. Results The mean difference in pre- and post-RT PD was −0.38% ± 3.20% ( P =.68), with no clinically significant defects. To assess for subclinical effects, PD were also examined using a 1.5-SD below the normal mean threshold, with a mean difference of 2.53% ± 12.57% ( P =.38). The mean differences in SSS and EF before and after RT were 0.78% ± 2.50% ( P =.08) and 1.75% ± 7.29% ( P =.39), respectively. The average heart Dmean and D95 were 2.82 Gy (range, 1.11-6.06 Gy) and 0.90 Gy (range, 0.13-2.17 Gy), respectively. The average Dmean and D95 to the left anterior descending artery were 7.22 Gy (range, 2.58-18.05 Gy) and 3.22 Gy (range, 1.23-6.86 Gy), respectively. No correlations were found between cardiac doses and changes in PD, SSS, and EF. Conclusions Using sensitive measures of cardiac function, no clinically significant defects were found after RT, with the average heart Dmean |
| doi_str_mv | 10.1016/j.ijrobp.2012.08.002 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5175458</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0360301612033883</els_id><sourcerecordid>1687665631</sourcerecordid><originalsourceid>FETCH-LOGICAL-c579t-250cdca1e571019bf0e6f5084cf624c566d2b820eb2abc0c5e89b6d0947099a33</originalsourceid><addsrcrecordid>eNqFUk1v1DAQjRCIbgv_AKFIXLgkjO3YcS4g1AKttBLSUkRvluNMiEM2Tu1s0f77Ot1SPi6cbGnee_Nm3iTJCwI5ASLe9LntvaunnAKhOcgcgD5KVkSWVcY4v3qcrIAJyFgEHyXHIfQAQEhZPE2OKANKSqhWydVFSC879Jjq9MwFzDYYJjcGTDc46NnGb2entHU-PUft5_TMBtSx_M3OXbp2P7OFlW50Y-_Qd2J62r97ljxp9RDw-f17knz9-OHy9Dxbf_50cfp-nRleVnNGOZjGaIK8jFNVdQsoWg6yMK2gheFCNLSWFLCmujZgOMqqFg1URbRfacZOkrcH3WlXb7ExOM5eD2rydqv9Xjlt1d-V0Xbqu7tRnJS84DIKvDoIuDBbFYyd0XTGjSOaWVFaUKDVgnp938a76x2GWW1tMDgMekS3C4oIWQrBBSMRWhygxrsQPLYPZgioJTrVq0N0aolOgVQxukh7-ecgD6RfWf2eFOM6byz6xSyOBhvrF6-Ns__r8K-AGexojR5-4B5D73Z-jFEpokLkqC_L-SzXQygwJiVjt5ouwMw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1687665631</pqid></control><display><type>article</type><title>Is There a Dose-Response Relationship for Heart Disease With Low-Dose Radiation Therapy?</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Chung, Eugene, MD, PhD, JD ; Corbett, James R., MD ; Moran, Jean M., PhD ; Griffith, Kent A., MS ; Marsh, Robin B., CMD ; Feng, Mary, MD ; Jagsi, Reshma, MD, DPhil ; Kessler, Marc L., PhD ; Ficaro, Edward C., PhD ; Pierce, Lori J., MD</creator><creatorcontrib>Chung, Eugene, MD, PhD, JD ; Corbett, James R., MD ; Moran, Jean M., PhD ; Griffith, Kent A., MS ; Marsh, Robin B., CMD ; Feng, Mary, MD ; Jagsi, Reshma, MD, DPhil ; Kessler, Marc L., PhD ; Ficaro, Edward C., PhD ; Pierce, Lori J., MD</creatorcontrib><description>Purpose To quantify cardiac radiation therapy (RT) exposure using sensitive measures of cardiac dysfunction; and to correlate dysfunction with heart doses, in the setting of adjuvant RT for left-sided breast cancer. Methods and Materials On a randomized trial, 32 women with node-positive left-sided breast cancer underwent pre-RT stress single photon emission computed tomography (SPECT-CT) myocardial perfusion scans. Patients received RT to the breast/chest wall and regional lymph nodes to doses of 50 to 52.2 Gy. Repeat SPECT-CT scans were performed 1 year after RT. Perfusion defects (PD), summed stress defects scores (SSS), and ejection fractions (EF) were evaluated. Doses to the heart and coronary arteries were quantified. Results The mean difference in pre- and post-RT PD was −0.38% ± 3.20% ( P =.68), with no clinically significant defects. To assess for subclinical effects, PD were also examined using a 1.5-SD below the normal mean threshold, with a mean difference of 2.53% ± 12.57% ( P =.38). The mean differences in SSS and EF before and after RT were 0.78% ± 2.50% ( P =.08) and 1.75% ± 7.29% ( P =.39), respectively. The average heart Dmean and D95 were 2.82 Gy (range, 1.11-6.06 Gy) and 0.90 Gy (range, 0.13-2.17 Gy), respectively. The average Dmean and D95 to the left anterior descending artery were 7.22 Gy (range, 2.58-18.05 Gy) and 3.22 Gy (range, 1.23-6.86 Gy), respectively. No correlations were found between cardiac doses and changes in PD, SSS, and EF. Conclusions Using sensitive measures of cardiac function, no clinically significant defects were found after RT, with the average heart Dmean <5 Gy. Although a dose response may exist for measures of cardiac dysfunction at higher doses, no correlation was found in the present study for low doses delivered to cardiac structures and perfusion, SSS, or EF.</description><identifier>ISSN: 0360-3016</identifier><identifier>EISSN: 1879-355X</identifier><identifier>DOI: 10.1016/j.ijrobp.2012.08.002</identifier><identifier>PMID: 23021709</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; Breast Neoplasms - pathology ; Breast Neoplasms - radiotherapy ; CARDIOVASCULAR DISEASES ; CAT SCANNING ; CHEST ; CORONARIES ; Coronary Vessels - physiopathology ; Coronary Vessels - radiation effects ; Dose-Response Relationship, Radiation ; DOSE-RESPONSE RELATIONSHIPS ; Female ; GY RANGE 01-10 ; GY RANGE 10-100 ; HEART ; Heart - diagnostic imaging ; Heart - physiopathology ; Heart - radiation effects ; Hematology, Oncology and Palliative Medicine ; Humans ; LYMPH NODES ; MAMMARY GLANDS ; Middle Aged ; Multimodal Imaging ; Myocardial Perfusion Imaging - methods ; NEOPLASMS ; Organs at Risk - diagnostic imaging ; Organs at Risk - physiopathology ; Organs at Risk - radiation effects ; PATIENTS ; Positron-Emission Tomography ; Prospective Studies ; RADIATION DOSES ; Radiology ; RADIOLOGY AND NUCLEAR MEDICINE ; RADIOTHERAPY ; Radiotherapy, Adjuvant - adverse effects ; Radiotherapy, Adjuvant - methods ; Radiotherapy, Conformal - adverse effects ; Radiotherapy, Conformal - methods ; Radiotherapy, Intensity-Modulated - adverse effects ; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY ; Stroke Volume - physiology ; Stroke Volume - radiation effects ; Tomography, X-Ray Computed ; WOMEN</subject><ispartof>International journal of radiation oncology, biology, physics, 2013-03, Vol.85 (4), p.959-964</ispartof><rights>Elsevier Inc.</rights><rights>2013 Elsevier Inc.</rights><rights>Copyright © 2013 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c579t-250cdca1e571019bf0e6f5084cf624c566d2b820eb2abc0c5e89b6d0947099a33</citedby><cites>FETCH-LOGICAL-c579t-250cdca1e571019bf0e6f5084cf624c566d2b820eb2abc0c5e89b6d0947099a33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0360301612033883$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23021709$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/22420298$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Chung, Eugene, MD, PhD, JD</creatorcontrib><creatorcontrib>Corbett, James R., MD</creatorcontrib><creatorcontrib>Moran, Jean M., PhD</creatorcontrib><creatorcontrib>Griffith, Kent A., MS</creatorcontrib><creatorcontrib>Marsh, Robin B., CMD</creatorcontrib><creatorcontrib>Feng, Mary, MD</creatorcontrib><creatorcontrib>Jagsi, Reshma, MD, DPhil</creatorcontrib><creatorcontrib>Kessler, Marc L., PhD</creatorcontrib><creatorcontrib>Ficaro, Edward C., PhD</creatorcontrib><creatorcontrib>Pierce, Lori J., MD</creatorcontrib><title>Is There a Dose-Response Relationship for Heart Disease With Low-Dose Radiation Therapy?</title><title>International journal of radiation oncology, biology, physics</title><addtitle>Int J Radiat Oncol Biol Phys</addtitle><description>Purpose To quantify cardiac radiation therapy (RT) exposure using sensitive measures of cardiac dysfunction; and to correlate dysfunction with heart doses, in the setting of adjuvant RT for left-sided breast cancer. Methods and Materials On a randomized trial, 32 women with node-positive left-sided breast cancer underwent pre-RT stress single photon emission computed tomography (SPECT-CT) myocardial perfusion scans. Patients received RT to the breast/chest wall and regional lymph nodes to doses of 50 to 52.2 Gy. Repeat SPECT-CT scans were performed 1 year after RT. Perfusion defects (PD), summed stress defects scores (SSS), and ejection fractions (EF) were evaluated. Doses to the heart and coronary arteries were quantified. Results The mean difference in pre- and post-RT PD was −0.38% ± 3.20% ( P =.68), with no clinically significant defects. To assess for subclinical effects, PD were also examined using a 1.5-SD below the normal mean threshold, with a mean difference of 2.53% ± 12.57% ( P =.38). The mean differences in SSS and EF before and after RT were 0.78% ± 2.50% ( P =.08) and 1.75% ± 7.29% ( P =.39), respectively. The average heart Dmean and D95 were 2.82 Gy (range, 1.11-6.06 Gy) and 0.90 Gy (range, 0.13-2.17 Gy), respectively. The average Dmean and D95 to the left anterior descending artery were 7.22 Gy (range, 2.58-18.05 Gy) and 3.22 Gy (range, 1.23-6.86 Gy), respectively. No correlations were found between cardiac doses and changes in PD, SSS, and EF. Conclusions Using sensitive measures of cardiac function, no clinically significant defects were found after RT, with the average heart Dmean <5 Gy. Although a dose response may exist for measures of cardiac dysfunction at higher doses, no correlation was found in the present study for low doses delivered to cardiac structures and perfusion, SSS, or EF.</description><subject>Adult</subject><subject>Aged</subject><subject>Breast Neoplasms - pathology</subject><subject>Breast Neoplasms - radiotherapy</subject><subject>CARDIOVASCULAR DISEASES</subject><subject>CAT SCANNING</subject><subject>CHEST</subject><subject>CORONARIES</subject><subject>Coronary Vessels - physiopathology</subject><subject>Coronary Vessels - radiation effects</subject><subject>Dose-Response Relationship, Radiation</subject><subject>DOSE-RESPONSE RELATIONSHIPS</subject><subject>Female</subject><subject>GY RANGE 01-10</subject><subject>GY RANGE 10-100</subject><subject>HEART</subject><subject>Heart - diagnostic imaging</subject><subject>Heart - physiopathology</subject><subject>Heart - radiation effects</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>LYMPH NODES</subject><subject>MAMMARY GLANDS</subject><subject>Middle Aged</subject><subject>Multimodal Imaging</subject><subject>Myocardial Perfusion Imaging - methods</subject><subject>NEOPLASMS</subject><subject>Organs at Risk - diagnostic imaging</subject><subject>Organs at Risk - physiopathology</subject><subject>Organs at Risk - radiation effects</subject><subject>PATIENTS</subject><subject>Positron-Emission Tomography</subject><subject>Prospective Studies</subject><subject>RADIATION DOSES</subject><subject>Radiology</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>RADIOTHERAPY</subject><subject>Radiotherapy, Adjuvant - adverse effects</subject><subject>Radiotherapy, Adjuvant - methods</subject><subject>Radiotherapy, Conformal - adverse effects</subject><subject>Radiotherapy, Conformal - methods</subject><subject>Radiotherapy, Intensity-Modulated - adverse effects</subject><subject>SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY</subject><subject>Stroke Volume - physiology</subject><subject>Stroke Volume - radiation effects</subject><subject>Tomography, X-Ray Computed</subject><subject>WOMEN</subject><issn>0360-3016</issn><issn>1879-355X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUk1v1DAQjRCIbgv_AKFIXLgkjO3YcS4g1AKttBLSUkRvluNMiEM2Tu1s0f77Ot1SPi6cbGnee_Nm3iTJCwI5ASLe9LntvaunnAKhOcgcgD5KVkSWVcY4v3qcrIAJyFgEHyXHIfQAQEhZPE2OKANKSqhWydVFSC879Jjq9MwFzDYYJjcGTDc46NnGb2entHU-PUft5_TMBtSx_M3OXbp2P7OFlW50Y-_Qd2J62r97ljxp9RDw-f17knz9-OHy9Dxbf_50cfp-nRleVnNGOZjGaIK8jFNVdQsoWg6yMK2gheFCNLSWFLCmujZgOMqqFg1URbRfacZOkrcH3WlXb7ExOM5eD2rydqv9Xjlt1d-V0Xbqu7tRnJS84DIKvDoIuDBbFYyd0XTGjSOaWVFaUKDVgnp938a76x2GWW1tMDgMekS3C4oIWQrBBSMRWhygxrsQPLYPZgioJTrVq0N0aolOgVQxukh7-ecgD6RfWf2eFOM6byz6xSyOBhvrF6-Ns__r8K-AGexojR5-4B5D73Z-jFEpokLkqC_L-SzXQygwJiVjt5ouwMw</recordid><startdate>20130315</startdate><enddate>20130315</enddate><creator>Chung, Eugene, MD, PhD, JD</creator><creator>Corbett, James R., MD</creator><creator>Moran, Jean M., PhD</creator><creator>Griffith, Kent A., MS</creator><creator>Marsh, Robin B., CMD</creator><creator>Feng, Mary, MD</creator><creator>Jagsi, Reshma, MD, DPhil</creator><creator>Kessler, Marc L., PhD</creator><creator>Ficaro, Edward C., PhD</creator><creator>Pierce, Lori J., MD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>OTOTI</scope><scope>5PM</scope></search><sort><creationdate>20130315</creationdate><title>Is There a Dose-Response Relationship for Heart Disease With Low-Dose Radiation Therapy?</title><author>Chung, Eugene, MD, PhD, JD ; Corbett, James R., MD ; Moran, Jean M., PhD ; Griffith, Kent A., MS ; Marsh, Robin B., CMD ; Feng, Mary, MD ; Jagsi, Reshma, MD, DPhil ; Kessler, Marc L., PhD ; Ficaro, Edward C., PhD ; Pierce, Lori J., MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c579t-250cdca1e571019bf0e6f5084cf624c566d2b820eb2abc0c5e89b6d0947099a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Breast Neoplasms - pathology</topic><topic>Breast Neoplasms - radiotherapy</topic><topic>CARDIOVASCULAR DISEASES</topic><topic>CAT SCANNING</topic><topic>CHEST</topic><topic>CORONARIES</topic><topic>Coronary Vessels - physiopathology</topic><topic>Coronary Vessels - radiation effects</topic><topic>Dose-Response Relationship, Radiation</topic><topic>DOSE-RESPONSE RELATIONSHIPS</topic><topic>Female</topic><topic>GY RANGE 01-10</topic><topic>GY RANGE 10-100</topic><topic>HEART</topic><topic>Heart - diagnostic imaging</topic><topic>Heart - physiopathology</topic><topic>Heart - radiation effects</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>LYMPH NODES</topic><topic>MAMMARY GLANDS</topic><topic>Middle Aged</topic><topic>Multimodal Imaging</topic><topic>Myocardial Perfusion Imaging - methods</topic><topic>NEOPLASMS</topic><topic>Organs at Risk - diagnostic imaging</topic><topic>Organs at Risk - physiopathology</topic><topic>Organs at Risk - radiation effects</topic><topic>PATIENTS</topic><topic>Positron-Emission Tomography</topic><topic>Prospective Studies</topic><topic>RADIATION DOSES</topic><topic>Radiology</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>RADIOTHERAPY</topic><topic>Radiotherapy, Adjuvant - adverse effects</topic><topic>Radiotherapy, Adjuvant - methods</topic><topic>Radiotherapy, Conformal - adverse effects</topic><topic>Radiotherapy, Conformal - methods</topic><topic>Radiotherapy, Intensity-Modulated - adverse effects</topic><topic>SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY</topic><topic>Stroke Volume - physiology</topic><topic>Stroke Volume - radiation effects</topic><topic>Tomography, X-Ray Computed</topic><topic>WOMEN</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chung, Eugene, MD, PhD, JD</creatorcontrib><creatorcontrib>Corbett, James R., MD</creatorcontrib><creatorcontrib>Moran, Jean M., PhD</creatorcontrib><creatorcontrib>Griffith, Kent A., MS</creatorcontrib><creatorcontrib>Marsh, Robin B., CMD</creatorcontrib><creatorcontrib>Feng, Mary, MD</creatorcontrib><creatorcontrib>Jagsi, Reshma, MD, DPhil</creatorcontrib><creatorcontrib>Kessler, Marc L., PhD</creatorcontrib><creatorcontrib>Ficaro, Edward C., PhD</creatorcontrib><creatorcontrib>Pierce, Lori J., MD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>OSTI.GOV</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of radiation oncology, biology, physics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chung, Eugene, MD, PhD, JD</au><au>Corbett, James R., MD</au><au>Moran, Jean M., PhD</au><au>Griffith, Kent A., MS</au><au>Marsh, Robin B., CMD</au><au>Feng, Mary, MD</au><au>Jagsi, Reshma, MD, DPhil</au><au>Kessler, Marc L., PhD</au><au>Ficaro, Edward C., PhD</au><au>Pierce, Lori J., MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Is There a Dose-Response Relationship for Heart Disease With Low-Dose Radiation Therapy?</atitle><jtitle>International journal of radiation oncology, biology, physics</jtitle><addtitle>Int J Radiat Oncol Biol Phys</addtitle><date>2013-03-15</date><risdate>2013</risdate><volume>85</volume><issue>4</issue><spage>959</spage><epage>964</epage><pages>959-964</pages><issn>0360-3016</issn><eissn>1879-355X</eissn><abstract>Purpose To quantify cardiac radiation therapy (RT) exposure using sensitive measures of cardiac dysfunction; and to correlate dysfunction with heart doses, in the setting of adjuvant RT for left-sided breast cancer. Methods and Materials On a randomized trial, 32 women with node-positive left-sided breast cancer underwent pre-RT stress single photon emission computed tomography (SPECT-CT) myocardial perfusion scans. Patients received RT to the breast/chest wall and regional lymph nodes to doses of 50 to 52.2 Gy. Repeat SPECT-CT scans were performed 1 year after RT. Perfusion defects (PD), summed stress defects scores (SSS), and ejection fractions (EF) were evaluated. Doses to the heart and coronary arteries were quantified. Results The mean difference in pre- and post-RT PD was −0.38% ± 3.20% ( P =.68), with no clinically significant defects. To assess for subclinical effects, PD were also examined using a 1.5-SD below the normal mean threshold, with a mean difference of 2.53% ± 12.57% ( P =.38). The mean differences in SSS and EF before and after RT were 0.78% ± 2.50% ( P =.08) and 1.75% ± 7.29% ( P =.39), respectively. The average heart Dmean and D95 were 2.82 Gy (range, 1.11-6.06 Gy) and 0.90 Gy (range, 0.13-2.17 Gy), respectively. The average Dmean and D95 to the left anterior descending artery were 7.22 Gy (range, 2.58-18.05 Gy) and 3.22 Gy (range, 1.23-6.86 Gy), respectively. No correlations were found between cardiac doses and changes in PD, SSS, and EF. Conclusions Using sensitive measures of cardiac function, no clinically significant defects were found after RT, with the average heart Dmean <5 Gy. Although a dose response may exist for measures of cardiac dysfunction at higher doses, no correlation was found in the present study for low doses delivered to cardiac structures and perfusion, SSS, or EF.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>23021709</pmid><doi>10.1016/j.ijrobp.2012.08.002</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Breast Neoplasms - pathology Breast Neoplasms - radiotherapy CARDIOVASCULAR DISEASES CAT SCANNING CHEST CORONARIES Coronary Vessels - physiopathology Coronary Vessels - radiation effects Dose-Response Relationship, Radiation DOSE-RESPONSE RELATIONSHIPS Female GY RANGE 01-10 GY RANGE 10-100 HEART Heart - diagnostic imaging Heart - physiopathology Heart - radiation effects Hematology, Oncology and Palliative Medicine Humans LYMPH NODES MAMMARY GLANDS Middle Aged Multimodal Imaging Myocardial Perfusion Imaging - methods NEOPLASMS Organs at Risk - diagnostic imaging Organs at Risk - physiopathology Organs at Risk - radiation effects PATIENTS Positron-Emission Tomography Prospective Studies RADIATION DOSES Radiology RADIOLOGY AND NUCLEAR MEDICINE RADIOTHERAPY Radiotherapy, Adjuvant - adverse effects Radiotherapy, Adjuvant - methods Radiotherapy, Conformal - adverse effects Radiotherapy, Conformal - methods Radiotherapy, Intensity-Modulated - adverse effects SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY Stroke Volume - physiology Stroke Volume - radiation effects Tomography, X-Ray Computed WOMEN |
| title | Is There a Dose-Response Relationship for Heart Disease With Low-Dose Radiation Therapy? |
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