Genetic Analysis of BDNF , GNB3 , MTHFR , ACE and APOE Variants in Major and Recurrent Depressive Disorders in Russia
This study was conducted to explore the possibility of association between the single-nucleotide polymorphisms rs6264 of , rs5443 of , and rs1801133 of ; the polymorphism of ; and the allele of and major depressive disorder (MDD) and recurrent depressive disorder (RDD) in an East Slavic population....
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| Veröffentlicht in: | International journal of medical sciences 2016-01, Vol.13 (12), p.977-983 |
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| creator | Bondarenko, E A Shadrina, M I Grishkina, M N Druzhkova, T A Akzhigitov, R G Gulyaeva, N V Guekht, A B Slominsky, P A |
| description | This study was conducted to explore the possibility of association between the single-nucleotide polymorphisms rs6264 of
, rs5443 of
, and rs1801133 of
; the
polymorphism of
; and the
allele of
and major depressive disorder (MDD) and recurrent depressive disorder (RDD) in an East Slavic population. Generalized multifactor dimensionality reduction (GMDR) method was applied to detect gene-gene interactions. One hundred fifty patients with RDD (101 females and 49 males) and 208 patients with MDD (115 females and 93 males) were included in the study. The comparison group consisted of 200 unrelated individuals. There was no significant difference in genotype distributions or allele frequencies between the controls and any of the diagnostic groups. Nevertheless, the frequency of the
allele of rs1801133 of
was higher in the RDD group and the frequency of the
allele of rs6264 of
was higher in the MDD group. The difference between the controls and specific disease groups almost reached statistical significance (
= 0.08). A GMDR did not reveal optimal two- and three-dimensional models with significant prediction accuracies (
˃ 0.05) for the MDD or RDD groups. |
| doi_str_mv | 10.7150/ijms.16642 |
| format | Article |
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, rs5443 of
, and rs1801133 of
; the
polymorphism of
; and the
allele of
and major depressive disorder (MDD) and recurrent depressive disorder (RDD) in an East Slavic population. Generalized multifactor dimensionality reduction (GMDR) method was applied to detect gene-gene interactions. One hundred fifty patients with RDD (101 females and 49 males) and 208 patients with MDD (115 females and 93 males) were included in the study. The comparison group consisted of 200 unrelated individuals. There was no significant difference in genotype distributions or allele frequencies between the controls and any of the diagnostic groups. Nevertheless, the frequency of the
allele of rs1801133 of
was higher in the RDD group and the frequency of the
allele of rs6264 of
was higher in the MDD group. The difference between the controls and specific disease groups almost reached statistical significance (
= 0.08). A GMDR did not reveal optimal two- and three-dimensional models with significant prediction accuracies (
˃ 0.05) for the MDD or RDD groups.</description><identifier>ISSN: 1449-1907</identifier><identifier>EISSN: 1449-1907</identifier><identifier>DOI: 10.7150/ijms.16642</identifier><identifier>PMID: 27994504</identifier><language>eng</language><publisher>Australia: Ivyspring International Publisher</publisher><subject>Adult ; Apolipoproteins E - genetics ; Asian Continental Ancestry Group ; Brain-Derived Neurotrophic Factor - genetics ; Depressive Disorder, Major - epidemiology ; Depressive Disorder, Major - genetics ; Female ; Gene Frequency - genetics ; Genetic Predisposition to Disease - genetics ; Genotype ; Haplotypes - genetics ; Heterotrimeric GTP-Binding Proteins - genetics ; Humans ; Male ; Methylenetetrahydrofolate Reductase (NADPH2) - genetics ; Peptidyl-Dipeptidase A - genetics ; Polymorphism, Genetic - genetics ; Research Paper ; Risk Factors ; Russia - epidemiology</subject><ispartof>International journal of medical sciences, 2016-01, Vol.13 (12), p.977-983</ispartof><rights>Ivyspring International Publisher. This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions. 2016</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c378t-df4cacd38fb68d0f62f724d7ce60601c0ccd1bf6da07a9535c0539c1b5fd6ec13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5165692/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5165692/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27994504$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bondarenko, E A</creatorcontrib><creatorcontrib>Shadrina, M I</creatorcontrib><creatorcontrib>Grishkina, M N</creatorcontrib><creatorcontrib>Druzhkova, T A</creatorcontrib><creatorcontrib>Akzhigitov, R G</creatorcontrib><creatorcontrib>Gulyaeva, N V</creatorcontrib><creatorcontrib>Guekht, A B</creatorcontrib><creatorcontrib>Slominsky, P A</creatorcontrib><title>Genetic Analysis of BDNF , GNB3 , MTHFR , ACE and APOE Variants in Major and Recurrent Depressive Disorders in Russia</title><title>International journal of medical sciences</title><addtitle>Int J Med Sci</addtitle><description>This study was conducted to explore the possibility of association between the single-nucleotide polymorphisms rs6264 of
, rs5443 of
, and rs1801133 of
; the
polymorphism of
; and the
allele of
and major depressive disorder (MDD) and recurrent depressive disorder (RDD) in an East Slavic population. Generalized multifactor dimensionality reduction (GMDR) method was applied to detect gene-gene interactions. One hundred fifty patients with RDD (101 females and 49 males) and 208 patients with MDD (115 females and 93 males) were included in the study. The comparison group consisted of 200 unrelated individuals. There was no significant difference in genotype distributions or allele frequencies between the controls and any of the diagnostic groups. Nevertheless, the frequency of the
allele of rs1801133 of
was higher in the RDD group and the frequency of the
allele of rs6264 of
was higher in the MDD group. The difference between the controls and specific disease groups almost reached statistical significance (
= 0.08). A GMDR did not reveal optimal two- and three-dimensional models with significant prediction accuracies (
˃ 0.05) for the MDD or RDD groups.</description><subject>Adult</subject><subject>Apolipoproteins E - genetics</subject><subject>Asian Continental Ancestry Group</subject><subject>Brain-Derived Neurotrophic Factor - genetics</subject><subject>Depressive Disorder, Major - epidemiology</subject><subject>Depressive Disorder, Major - genetics</subject><subject>Female</subject><subject>Gene Frequency - genetics</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genotype</subject><subject>Haplotypes - genetics</subject><subject>Heterotrimeric GTP-Binding Proteins - genetics</subject><subject>Humans</subject><subject>Male</subject><subject>Methylenetetrahydrofolate Reductase (NADPH2) - genetics</subject><subject>Peptidyl-Dipeptidase A - genetics</subject><subject>Polymorphism, Genetic - genetics</subject><subject>Research Paper</subject><subject>Risk Factors</subject><subject>Russia - epidemiology</subject><issn>1449-1907</issn><issn>1449-1907</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkUtLAzEUhYMoPqobf4BkKWJrMplkJhth-lSwrRR1G9I8NGU6U5OZQv-901ZFV-dy78e5Bw4Alxh1EkzRnVssQwczFkcH4BTHMW9jjpLDP_MJOAthgRCJSIKPwUmUcB5TFJ-CemQKUzkFs0Lmm-ACLC3s9idDeAtHky5pZPzyMJw1mvUGUBYaZs_TAXyT3smiCtAVcCwXpd-dZkbV3puign2z8iYEtzaw70LptfE7dlY3S3kOjqzMg7n41hZ4HQ5eeg_tp-nosZc9tRVJ0qqtbayk0iS1c5ZqZFlkkyjWiTIMMYQVUkrjuWVaokRySqhClHCF59RqZhQmLXC_913V86XRqknmZS5W3i2l34hSOvH_UrgP8V6uBcWMMh41BtffBr78rE2oxNIFZfJcFqasg8ApxRFPKUcNerNHlS9D8Mb-vsFIbHsS257ErqcGvvob7Bf9KYZ8ARC2jc4</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Bondarenko, E A</creator><creator>Shadrina, M I</creator><creator>Grishkina, M N</creator><creator>Druzhkova, T A</creator><creator>Akzhigitov, R G</creator><creator>Gulyaeva, N V</creator><creator>Guekht, A B</creator><creator>Slominsky, P A</creator><general>Ivyspring International Publisher</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160101</creationdate><title>Genetic Analysis of BDNF , GNB3 , MTHFR , ACE and APOE Variants in Major and Recurrent Depressive Disorders in Russia</title><author>Bondarenko, E A ; Shadrina, M I ; Grishkina, M N ; Druzhkova, T A ; Akzhigitov, R G ; Gulyaeva, N V ; Guekht, A B ; Slominsky, P A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c378t-df4cacd38fb68d0f62f724d7ce60601c0ccd1bf6da07a9535c0539c1b5fd6ec13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Apolipoproteins E - genetics</topic><topic>Asian Continental Ancestry Group</topic><topic>Brain-Derived Neurotrophic Factor - genetics</topic><topic>Depressive Disorder, Major - epidemiology</topic><topic>Depressive Disorder, Major - genetics</topic><topic>Female</topic><topic>Gene Frequency - genetics</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Genotype</topic><topic>Haplotypes - genetics</topic><topic>Heterotrimeric GTP-Binding Proteins - genetics</topic><topic>Humans</topic><topic>Male</topic><topic>Methylenetetrahydrofolate Reductase (NADPH2) - genetics</topic><topic>Peptidyl-Dipeptidase A - genetics</topic><topic>Polymorphism, Genetic - genetics</topic><topic>Research Paper</topic><topic>Risk Factors</topic><topic>Russia - epidemiology</topic><toplevel>online_resources</toplevel><creatorcontrib>Bondarenko, E A</creatorcontrib><creatorcontrib>Shadrina, M I</creatorcontrib><creatorcontrib>Grishkina, M N</creatorcontrib><creatorcontrib>Druzhkova, T A</creatorcontrib><creatorcontrib>Akzhigitov, R G</creatorcontrib><creatorcontrib>Gulyaeva, N V</creatorcontrib><creatorcontrib>Guekht, A B</creatorcontrib><creatorcontrib>Slominsky, P A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bondarenko, E A</au><au>Shadrina, M I</au><au>Grishkina, M N</au><au>Druzhkova, T A</au><au>Akzhigitov, R G</au><au>Gulyaeva, N V</au><au>Guekht, A B</au><au>Slominsky, P A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic Analysis of BDNF , GNB3 , MTHFR , ACE and APOE Variants in Major and Recurrent Depressive Disorders in Russia</atitle><jtitle>International journal of medical sciences</jtitle><addtitle>Int J Med Sci</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>13</volume><issue>12</issue><spage>977</spage><epage>983</epage><pages>977-983</pages><issn>1449-1907</issn><eissn>1449-1907</eissn><abstract>This study was conducted to explore the possibility of association between the single-nucleotide polymorphisms rs6264 of
, rs5443 of
, and rs1801133 of
; the
polymorphism of
; and the
allele of
and major depressive disorder (MDD) and recurrent depressive disorder (RDD) in an East Slavic population. Generalized multifactor dimensionality reduction (GMDR) method was applied to detect gene-gene interactions. One hundred fifty patients with RDD (101 females and 49 males) and 208 patients with MDD (115 females and 93 males) were included in the study. The comparison group consisted of 200 unrelated individuals. There was no significant difference in genotype distributions or allele frequencies between the controls and any of the diagnostic groups. Nevertheless, the frequency of the
allele of rs1801133 of
was higher in the RDD group and the frequency of the
allele of rs6264 of
was higher in the MDD group. The difference between the controls and specific disease groups almost reached statistical significance (
= 0.08). A GMDR did not reveal optimal two- and three-dimensional models with significant prediction accuracies (
˃ 0.05) for the MDD or RDD groups.</abstract><cop>Australia</cop><pub>Ivyspring International Publisher</pub><pmid>27994504</pmid><doi>10.7150/ijms.16642</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; PubMed Central Open Access |
| subjects | Adult Apolipoproteins E - genetics Asian Continental Ancestry Group Brain-Derived Neurotrophic Factor - genetics Depressive Disorder, Major - epidemiology Depressive Disorder, Major - genetics Female Gene Frequency - genetics Genetic Predisposition to Disease - genetics Genotype Haplotypes - genetics Heterotrimeric GTP-Binding Proteins - genetics Humans Male Methylenetetrahydrofolate Reductase (NADPH2) - genetics Peptidyl-Dipeptidase A - genetics Polymorphism, Genetic - genetics Research Paper Risk Factors Russia - epidemiology |
| title | Genetic Analysis of BDNF , GNB3 , MTHFR , ACE and APOE Variants in Major and Recurrent Depressive Disorders in Russia |
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