Genetic Analysis of BDNF , GNB3 , MTHFR , ACE and APOE Variants in Major and Recurrent Depressive Disorders in Russia

This study was conducted to explore the possibility of association between the single-nucleotide polymorphisms rs6264 of , rs5443 of , and rs1801133 of ; the polymorphism of ; and the allele of and major depressive disorder (MDD) and recurrent depressive disorder (RDD) in an East Slavic population. Generalized multifactor dimensionality reduction (GMDR) method was applied to detect gene-gene interactions. One hundred fifty patients with RDD (101 females and 49 males) and 208 patients with MDD (115 females and 93 males) were included in the study. The comparison group consisted of 200 unrelated individuals. There was no significant difference in genotype distributions or allele frequencies between the controls and any of the diagnostic groups. Nevertheless, the frequency of the allele of rs1801133 of was higher in the RDD group and the frequency of the allele of rs6264 of was higher in the MDD group. The difference between the controls and specific disease groups almost reached statistical significance ( = 0.08). A GMDR did not reveal optimal two- and three-dimensional models with significant prediction accuracies ( ˃ 0.05) for the MDD or RDD groups.