Protease regulation and capacity during Caulobacter growth

Highlights • An adaptor hierarchy controls staged protein degradation during cell cycle progression. • ClpXP balances dynamics of replication sliding clamps by proteolysis of both inhibitory and activating factors. • The Lon protease accommodates a wide range of substrates independent of sequence, b...

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Veröffentlicht in:	Current opinion in microbiology 2016-12, Vol.34, p.75-81
Hauptverfasser:	Vass, Robert H, Zeinert, Rilee D, Chien, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Proteins - genetics Bacterial Proteins - metabolism Caulobacter crescentus - enzymology Caulobacter crescentus - genetics Caulobacter crescentus - growth & development Cell Cycle - genetics Cell Division DNA Replication - genetics DNA, Bacterial Endopeptidase Clp - genetics Endopeptidase Clp - metabolism Gene Expression Regulation, Bacterial Pathology Peptide Hydrolases - genetics Peptide Hydrolases - metabolism Protease La - genetics Protease La - metabolism
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Beschreibung
Zusammenfassung:	Highlights • An adaptor hierarchy controls staged protein degradation during cell cycle progression. • ClpXP balances dynamics of replication sliding clamps by proteolysis of both inhibitory and activating factors. • The Lon protease accommodates a wide range of substrates independent of sequence, but also recognizes some specific targets based on sequence. • Saturation of proteases must be managed by additional regulation or compensation.
ISSN:	1369-5274 1879-0364
DOI:	10.1016/j.mib.2016.07.017