Restoration of foveal photoreceptors after intravitreal ranibizumab injections for diabetic macular edema

Anti-vascular endothelial growth factor drugs are the first-line treatment for diabetic macular edema (DME), although the mechanism of the visual acuity (VA) improvement remains largely unknown. The association between photoreceptor damage and visual impairment encouraged us to retrospectively inves...

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Veröffentlicht in:	Scientific reports 2016-12, Vol.6 (1), p.39161-39161, Article 39161
Hauptverfasser:	Mori, Yuki, Suzuma, Kiyoshi, Uji, Akihito, Ishihara, Kenji, Yoshitake, Shin, Fujimoto, Masahiro, Dodo, Yoko, Yoshitake, Tatsuya, Miwa, Yuko, Murakami, Tomoaki
Format:	Artikel
Sprache:	eng
Schlagworte:	692/53/2422 692/699/3161/3175 Acuity Diabetes Diabetes mellitus Diabetic retinopathy Edema Humanities and Social Sciences Immunotherapy Monoclonal antibodies multidisciplinary Photoreception Photoreceptors Retina Science Vascular endothelial growth factor
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Beschreibung
Zusammenfassung:	Anti-vascular endothelial growth factor drugs are the first-line treatment for diabetic macular edema (DME), although the mechanism of the visual acuity (VA) improvement remains largely unknown. The association between photoreceptor damage and visual impairment encouraged us to retrospectively investigate the changes in the foveal photoreceptors in the external limiting membrane (ELM) and ellipsoid zone (EZ) on spectral-domain optical coherence tomography (SD-OCT) images in 62 eyes with DME treated with intravitreal ranibizumab (IVR) injections. The transverse lengths of the disrupted EZ and ELM were shortened significantly ( P
ISSN:	2045-2322 2045-2322
DOI:	10.1038/srep39161