Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson’s disease: analysis of a large multi-center study

Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson’s disease: analysis of a large multi-center study

Abstract A recent study has shown that an interaction between variants at the LRRK2 and PARK16 loci influences risk of development of PD (MacLeod D. et al, 2013). Our study examines the proposed interaction between LRRK2 and PARK16 variants in modifying PD risk using a large multi-center series of P...

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Veröffentlicht in:Neurobiology of aging 2016-10, Vol.49, p.217.e1-217.e4
Hauptverfasser: Wang, L., MS, Heckman, M.G., MS, Aasly, J.O., MD, Annesi, G., PhD, Bozi, M., MD, Chung, S.J., MD, Clarke, C., MD, Crosiers, D., MD, Eckstein, G., PhD, Garraux, G., MD, Hadjigeorgiou, G.M., MD, Hattori, N., MD, PhD, Jeon, B., MD, Kim, Y.J., MD PhD, Kubo, M, Lesage, S., PhD, Lin, J.J., MD, Lynch, T., MD, Lichtner, P., PhD, Mellick, G.D., PhD, Mok, V., MD, Morrison, K.E., MD, Quattrone, A., MD, Satake, W., MD PhD, Silburn, P.A., MD, Stefanis, L., MD, Stockton, J.D., MD, Tan, E.K., MD, Toda, T., MD PhD, Brice, A., MD, Van Broeckhoven, C., PhD, Uitti, R.J., MD, Wirdefeldt, K., MD PhD, Wszolek, Z., MD, Xiromerisiou, G., MD, Maraganore, D.M., MD, Gasser, T., MD, Krüger, R., MD, Farrer, M.J., PhD, Ross, O.A., PhD, Sharma, M., PhD
Format: Artikel
Sprache:eng
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Internal Medicine
Neurology
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Zusammenfassung:Abstract A recent study has shown that an interaction between variants at the LRRK2 and PARK16 loci influences risk of development of PD (MacLeod D. et al, 2013). Our study examines the proposed interaction between LRRK2 and PARK16 variants in modifying PD risk using a large multi-center series of PD patients (5769) and controls (4988) from sites participating in the Genetic Epidemiology of Parkinson’s Disease (GEoPD) consortium. Our data does not support a strong direct interaction between LRRK2 and PARK16 variants; however given the role of retromer and lysosomal pathways in PD, further studies are warranted.
ISSN:0197-4580
1558-1497
DOI:10.1016/j.neurobiolaging.2016.09.022