Porous Silicon and Polymer Nanocomposites for Delivery of Peptide Nucleic Acids as Anti-MicroRNA Therapies

Self‐assembled polymer/porous silicon nanocomposites overcome intracellular and systemic barriers for in vivo application of peptide nucleic acid (PNA) anti‐microRNA therapeutics. Porous silicon (PSi) is leveraged as a biodegradable scaffold with high drug‐cargo‐loading capacity. Functionalization w...

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Veröffentlicht in:	Advanced materials (Weinheim) 2016-09, Vol.28 (36), p.7984-7992
Hauptverfasser:	Beavers, Kelsey R., Werfel, Thomas A., Shen, Tianwei, Kavanaugh, Taylor E., Kilchrist, Kameron V., Mares, Jeremy W., Fain, Joshua S., Wiese, Carrie B., Vickers, Kasey C., Weiss, Sharon M., Duvall, Craig L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals anti-miRNA Biodegradability Cell Line, Tumor Colloids - chemistry Female Humans Mice MicroRNAs - antagonists & inhibitors MicroRNAs - genetics nanocomposite Nanocomposites Nanocomposites - chemistry Nanostructure Nucleic acids peptide nucleic acids Peptide Nucleic Acids - administration & dosage Peptide Nucleic Acids - pharmacology Peptide Nucleic Acids - therapeutic use Peptides Pharmacology PNA Polymers - chemistry Porosity Porous silicon RNAi Therapeutics Silicon - chemistry Stability
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Zusammenfassung:	Self‐assembled polymer/porous silicon nanocomposites overcome intracellular and systemic barriers for in vivo application of peptide nucleic acid (PNA) anti‐microRNA therapeutics. Porous silicon (PSi) is leveraged as a biodegradable scaffold with high drug‐cargo‐loading capacity. Functionalization with a diblock polymer improves PSi nanoparticle colloidal stability, in vivo pharmacokinetics, and intracellular bioavailability through endosomal escape, enabling PNA to inhibit miR‐122 in vivo.
ISSN:	0935-9648 1521-4095
DOI:	10.1002/adma.201601646