Genome-Wide and Gene-Based Meta-Analyses Identify Novel Loci Influencing Blood Pressure Response to Hydrochlorothiazide

This study aimed to identify novel loci influencing the antihypertensive response to hydrochlorothiazide monotherapy. A genome-wide meta-analysis of blood pressure (BP) response to hydrochlorothiazide was performed in 1739 white hypertensives from 6 clinical trials within the International Consortiu...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2017-01, Vol.69 (1), p.51-59
Hauptverfasser:	Salvi, Erika, Wang, Zhiying, Rizzi, Federica, Gong, Yan, McDonough, Caitrin W, Padmanabhan, Sandosh, Hiltunen, Timo P, Lanzani, Chiara, Zaninello, Roberta, Chittani, Martina, Bailey, Kent R, Sarin, Antti-Pekka, Barcella, Matteo, Melander, Olle, Chapman, Arlene B, Manunta, Paolo, Kontula, Kimmo K, Glorioso, Nicola, Cusi, Daniele, Dominiczak, Anna F, Johnson, Julie A, Barlassina, Cristina, Boerwinkle, Eric, Cooper-DeHoff, Rhonda M, Turner, Stephen T
Format:	Artikel
Sprache:	eng
Schlagworte:	Diuretics - pharmacology Genome-Wide Association Study - methods Humans Hydrochlorothiazide - pharmacology Hypertension - drug therapy Hypertension - genetics Hypertension - physiopathology
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Beschreibung
Zusammenfassung:	This study aimed to identify novel loci influencing the antihypertensive response to hydrochlorothiazide monotherapy. A genome-wide meta-analysis of blood pressure (BP) response to hydrochlorothiazide was performed in 1739 white hypertensives from 6 clinical trials within the International Consortium for Antihypertensive Pharmacogenomics Studies, making it the largest study to date of its kind. No signals reached genome-wide significance (P
ISSN:	0194-911X 1524-4563
DOI:	10.1161/HYPERTENSIONAHA.116.08267