Raptor hunted by caspases

Emergence of survival strategies is a key step for organisms during evolution. The capacity to adapt from nutrient-rich to nutrient-poor environments led to the appearance of protein complexes regulating anabolic and catabolic pathways. The evolutionarily conserved kinase mTOR (mechanistic target of...

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Veröffentlicht in:	Cell death & disease 2016-06, Vol.7 (6), p.e2242-e2242
Hauptverfasser:	Martin, R, Thome, M, Martinon, F, Fasel, N
Format:	Artikel
Sprache:	eng
Schlagworte:	13/2 631/45/612/1234 631/80/82/23 631/80/86 692/699/67/1059 82 82/29 and Animals Antibodies Biochemistry Biomedical and Life Sciences Caspases - metabolism Cell Biology Cell Culture Environment Evolution Humans Immunology Kinases Life Sciences Mechanistic Target of Rapamycin Complex 1 - metabolism Models, Biological Neoplasms - metabolism news-and-commentary Nutrients Regulatory-Associated Protein of mTOR - metabolism
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Beschreibung
Zusammenfassung:	Emergence of survival strategies is a key step for organisms during evolution. The capacity to adapt from nutrient-rich to nutrient-poor environments led to the appearance of protein complexes regulating anabolic and catabolic pathways. The evolutionarily conserved kinase mTOR (mechanistic target of rapamycin) emerged as a crucial and central protein for regulating many different cellular functions in response to environmental changes.
ISSN:	2041-4889 2041-4889
DOI:	10.1038/cddis.2016.153