Expanding Clinical Laboratory Tobacco Product Evaluation Methods to Loose-leaf Tobacco Vaporizers

Highlights • This is the first human laboratory study of a loose-leaf tobacco vaporizer (LLTV). • LLTV use significantly increased plasma nicotine concentration, but not CO. • LLTV use reduced tobacco abstinence symptom severity, but less so than a cigarette. • Both the LLTV and an ECIG were signifi...

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Veröffentlicht in:	Drug and alcohol dependence 2016-12, Vol.169, p.33-40
Hauptverfasser:	Lopez, Alexa A, Hiler, Marzena, Maloney, Sarah, Eissenberg, Thomas, Breland, Alison
Format:	Artikel
Sprache:	eng
Schlagworte:	Abstinence Acute effects Adolescent Adult Brands Carbon monoxide Carbon Monoxide - blood Cigarettes Electronic cigarette Electronic Nicotine Delivery Systems Female Heat Heat-not-burn products Humans Laboratories Laboratory methods Leaves Loose-leaf tobacco vaporizer Male Markets Middle Aged Nebulizers and Vaporizers Nicotine Nicotine - blood Plasma nicotine Psychiatry Public Health Severity Smoking Smoking - blood Substance Withdrawal Syndrome - blood Symptoms Tobacco Tobacco Products Tobacco Use Disorder - blood Vaping - blood Vaporizers Young Adult
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Beschreibung
Zusammenfassung:	Highlights • This is the first human laboratory study of a loose-leaf tobacco vaporizer (LLTV). • LLTV use significantly increased plasma nicotine concentration, but not CO. • LLTV use reduced tobacco abstinence symptom severity, but less so than a cigarette. • Both the LLTV and an ECIG were significantly less satisfying than cigarettes. • Laboratory methods can be expanded to “heat-not-burn” products.
ISSN:	0376-8716 1879-0046 1879-0046
DOI:	10.1016/j.drugalcdep.2016.10.005