Cardioprotective effects of iron chelator HAPI and ROS-activated boronate prochelator BHAPI against catecholamine-induced oxidative cellular injury
Highlights • Fe prochelator BHAPI was examined for protection against catecholamine cardiotoxity. • BHAPI has no affinity for iron ions until it is activated to active chelator HAPI. • Catecholamines, as a source of ROS, induced conversion of BHAPI into HAPI. • BHAPI and HAPI decrease ROS formation...
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| Veröffentlicht in: | Toxicology (Amsterdam) 2016-09, Vol.371, p.17-28 |
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| container_title | Toxicology (Amsterdam) |
| container_volume | 371 |
| creator | Hašková, Pavlína Jansová, Hana Bureš, Jan Macháček, Miloslav Jirkovská, Anna Franz, Katherine J Kovaříková, Petra Šimůnek, Tomáš, Dr |
| description | Highlights • Fe prochelator BHAPI was examined for protection against catecholamine cardiotoxity. • BHAPI has no affinity for iron ions until it is activated to active chelator HAPI. • Catecholamines, as a source of ROS, induced conversion of BHAPI into HAPI. • BHAPI and HAPI decrease ROS formation induced by catecholamines. • BHAPI and HAPI protect H9c2 cells against oxidative injury induced by catecholamines. |
| doi_str_mv | 10.1016/j.tox.2016.10.004 |
| format | Article |
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drug effects</subject><subject>Oxidation</subject><subject>Oxidative Stress - drug effects</subject><subject>Prochelator</subject><subject>Prodrugs - pharmacology</subject><subject>Rats</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Semicarbazones - pharmacology</subject><subject>Stresses</subject><issn>0300-483X</issn><issn>1879-3185</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNksFu1DAQhiMEokvhAbggH7lkGcdO4hVSpbICWqlSEQWJmzVxJl0vWXuxk1X3OXhhHLasgAPi5LHnm98e_5NlzznMOfDq1Xo--Lt5kcK0nwPIB9mMq3qRC67Kh9kMBEAulfhykj2JcQ0AhZDV4-ykqGspQZaz7PsSQ2v9NviBzGB3xKjrUhSZ75gN3jGzoh4HH9jF-YdLhq5lH69vcpxgHKhljU9UiljSOLJvDvAtWhcHZlLarHyPG-sot64dTSr0d7bFn1ca6vuxx8CsW49h_zR71GEf6dn9epp9fvf20_Iiv7p-f7k8v8pNWRdDTgvFqYTGKNEtakBomw6aTkrEpkRQBlTRUGWEkkqWRrSyKRUWC2pBKIGFOM3ODrrbsdlQa8gNAXu9DXaDYa89Wv1nxtmVvvU7XXIha1kmgZf3AsF_GykOemPj1Aw68mPUXCkALkSp_gOtlBB1IXlC-QE1wccYqDu-iIOefNdrnXzXk-_TUfI91bz4vZVjxS-jE_D6AFD60J2loKOx5JIPNiS7devtP-XP_qo2vXXWYP-V9hTXfgwuOaW5joUGfTMN3jR3vBJp5BaV-AHzM9b7</recordid><startdate>20160914</startdate><enddate>20160914</enddate><creator>Hašková, Pavlína</creator><creator>Jansová, Hana</creator><creator>Bureš, Jan</creator><creator>Macháček, Miloslav</creator><creator>Jirkovská, Anna</creator><creator>Franz, Katherine J</creator><creator>Kovaříková, Petra</creator><creator>Šimůnek, Tomáš, Dr</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>7U7</scope><scope>C1K</scope><scope>SOI</scope><scope>8FD</scope><scope>FR3</scope><scope>KR7</scope><scope>5PM</scope></search><sort><creationdate>20160914</creationdate><title>Cardioprotective effects of iron chelator HAPI and ROS-activated boronate prochelator BHAPI against catecholamine-induced oxidative cellular injury</title><author>Hašková, Pavlína ; Jansová, Hana ; Bureš, Jan ; Macháček, Miloslav ; Jirkovská, Anna ; Franz, Katherine J ; Kovaříková, Petra ; Šimůnek, Tomáš, Dr</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c572t-e981e50bc83f970a0dbf0bf44aab5a08c082be6c384845c3d4b58a29ed0383a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>BHAPI</topic><topic>Biocatalysis</topic><topic>Boron Compounds - 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| fulltext | fulltext |
| identifier | ISSN: 0300-483X |
| ispartof | Toxicology (Amsterdam), 2016-09, Vol.371, p.17-28 |
| issn | 0300-483X 1879-3185 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals BHAPI Biocatalysis Boron Compounds - pharmacology Boronic Acids - pharmacology Cardiotonic Agents - pharmacology Cardiotoxicity Catecholamine Catecholamines Catecholamines - antagonists & inhibitors Catecholamines - toxicity Cell Line Chelating Chelation Emergency Epinephrine - antagonists & inhibitors Epinephrine - toxicity Formations Glutathione - metabolism HAPI Humans Hydroxyl Radical - metabolism Injuries Iron Iron - chemistry Iron Chelating Agents - pharmacology Iron chelation Isoproterenol - antagonists & inhibitors Isoproterenol - toxicity Membrane Potential, Mitochondrial - drug effects Oxidation Oxidative Stress - drug effects Prochelator Prodrugs - pharmacology Rats Reactive Oxygen Species - metabolism Semicarbazones - pharmacology Stresses |
| title | Cardioprotective effects of iron chelator HAPI and ROS-activated boronate prochelator BHAPI against catecholamine-induced oxidative cellular injury |
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