Cardioprotective effects of iron chelator HAPI and ROS-activated boronate prochelator BHAPI against catecholamine-induced oxidative cellular injury

Highlights • Fe prochelator BHAPI was examined for protection against catecholamine cardiotoxity. • BHAPI has no affinity for iron ions until it is activated to active chelator HAPI. • Catecholamines, as a source of ROS, induced conversion of BHAPI into HAPI. • BHAPI and HAPI decrease ROS formation...

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Veröffentlicht in:	Toxicology (Amsterdam) 2016-09, Vol.371, p.17-28
Hauptverfasser:	Hašková, Pavlína, Jansová, Hana, Bureš, Jan, Macháček, Miloslav, Jirkovská, Anna, Franz, Katherine J, Kovaříková, Petra, Šimůnek, Tomáš, Dr
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals BHAPI Biocatalysis Boron Compounds - pharmacology Boronic Acids - pharmacology Cardiotonic Agents - pharmacology Cardiotoxicity Catecholamine Catecholamines Catecholamines - antagonists & inhibitors Catecholamines - toxicity Cell Line Chelating Chelation Emergency Epinephrine - antagonists & inhibitors Epinephrine - toxicity Formations Glutathione - metabolism HAPI Humans Hydroxyl Radical - metabolism Injuries Iron Iron - chemistry Iron Chelating Agents - pharmacology Iron chelation Isoproterenol - antagonists & inhibitors Isoproterenol - toxicity Membrane Potential, Mitochondrial - drug effects Oxidation Oxidative Stress - drug effects Prochelator Prodrugs - pharmacology Rats Reactive Oxygen Species - metabolism Semicarbazones - pharmacology Stresses
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Zusammenfassung:	Highlights • Fe prochelator BHAPI was examined for protection against catecholamine cardiotoxity. • BHAPI has no affinity for iron ions until it is activated to active chelator HAPI. • Catecholamines, as a source of ROS, induced conversion of BHAPI into HAPI. • BHAPI and HAPI decrease ROS formation induced by catecholamines. • BHAPI and HAPI protect H9c2 cells against oxidative injury induced by catecholamines.
ISSN:	0300-483X 1879-3185
DOI:	10.1016/j.tox.2016.10.004