Transthyretin Cardiac Amyloidosis in Older Americans

Highlights • TTR cardiac amyloidosis is the quintessential form of diastolic heart failure that almost exclusively affects older adults • As the population ages, the diagnosis of ATTRwt will increase making it the most common form of cardiac amyloidosis. • A high index of suspicion is critical for making the diagnosis of cardiac amyloidosis. • Nuclear scintigraphy agents using99m Tc-phosphate derivatives combined with assessment for monoclonal proteins are eliminating the need for tissue confirmation in ATTR cardiac amyloid.