Cerebral Organoids in a Dish: Progress and Prospects

Cerebral Organoids in a Dish: Progress and Prospects

A three-dimensional culture of cortical tissues derived from pluripotent stem cells offers an opportunity to model human brain development and disorders. In a recent issue of Nature, Lancaster et al. describe a new method for generating cerebral organoids in a dish and use it to model microcephaly.

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Bibliographische Detailangaben
Veröffentlicht in:Cell 2013-09, Vol.155 (1), p.19-20
Hauptverfasser: Bershteyn, Marina, Kriegstein, Arnold R.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Brain - growth & development
Brain - pathology
Humans
Microcephaly - pathology
Models, Biological
Organoids - cytology
Organoids - growth & development
Tissue Culture Techniques - methods
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Beschreibung
Zusammenfassung:A three-dimensional culture of cortical tissues derived from pluripotent stem cells offers an opportunity to model human brain development and disorders. In a recent issue of Nature, Lancaster et al. describe a new method for generating cerebral organoids in a dish and use it to model microcephaly.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2013.09.010