Effect of HPV on head and neck cancer patient survival, by region and tumor site: A comparison of 1362 cases across three continents

Highlights • HNSCC survival was poorer among cases in Brazil than in the US and Europe. • HPV+/p16+ OPSCC predicted lower mortality in all 3 regions (US, Europe, Brazil). • HPV was not prognostic among non-OP HNSCC (OC, larynx, and HP). • Effect of HPV/p16 was significantly different in OPSCC &...

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Veröffentlicht in:	Oral oncology 2016-11, Vol.62, p.20-27
Hauptverfasser:	D’Souza, Gypsyamber, Anantharaman, Devasena, Gheit, Tarik, Abedi-Ardekani, Behnoush, Beachler, Daniel C, Conway, David I, Olshan, Andrew F, Wunsch-Filho, Victor, Toporcov, Tatiana N, Ahrens, Wolfgang, Wisniewski, Kathy, Merletti, Franco, Boccia, Stefania, Tajara, Eloiza H, Zevallos, Jose P, Levi, José Eduardo, Weissler, Mark C, Wright, Sylvia, Scelo, Ghislaine, Mazul, Angela L, Tommasino, Massimo, Cadoni, Gabriella, Brennan, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alphapapillomavirus - isolation & purification Brazil Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - virology Europe Female Head and Neck Neoplasms - pathology Head and Neck Neoplasms - virology Hematology, Oncology and Palliative Medicine HNSCC HPV Humans Male Middle Aged Non-OP Oral HPV Otolaryngology P16 Prognostic Risk factors Squamous Cell Carcinoma of Head and Neck Survival Survival Analysis
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Beschreibung
Zusammenfassung:	Highlights • HNSCC survival was poorer among cases in Brazil than in the US and Europe. • HPV+/p16+ OPSCC predicted lower mortality in all 3 regions (US, Europe, Brazil). • HPV was not prognostic among non-OP HNSCC (OC, larynx, and HP). • Effect of HPV/p16 was significantly different in OPSCC & non-OP HNSCC.
ISSN:	1368-8375 1879-0593
DOI:	10.1016/j.oraloncology.2016.09.005