Polymer fiber-based models of connective tissue repair and healing

Abstract Physiologically relevant models of wound healing are essential for understanding the biology of connective tissue repair and healing. They can also be used to identify key cellular processes and matrix characteristics essential for the design of soft tissue grafts. Modeling the various stag...

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Veröffentlicht in:	Biomaterials 2017-01, Vol.112, p.303-312
Hauptverfasser:	Lee, Nancy M, Erisken, Cevat, Iskratsch, Thomas, Sheetz, Michael, Levine, William N, Lu, Helen H
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Aged Alignment Cells, Cultured Connective tissue Connective Tissue - physiology Connective Tissue Cells - cytology Connective Tissue Cells - physiology Dentistry Female Fiber diameter Fibers Fibroblasts - cytology Fibroblasts - physiology Healing Humans Male Middle Aged Nanofibers Nanofibers - chemistry Nanofibers - ultrastructure Nanostructure Organizations Polymers - chemistry Repair Tendon Tendon Injuries - pathology Tendon Injuries - physiopathology Tissue Engineering - instrumentation Tissue Engineering - methods Tissue Scaffolds Wound Healing - physiology Wound repair model
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Beschreibung
Zusammenfassung:	Abstract Physiologically relevant models of wound healing are essential for understanding the biology of connective tissue repair and healing. They can also be used to identify key cellular processes and matrix characteristics essential for the design of soft tissue grafts. Modeling the various stages of repair post tendon injury, polymer meshes of varying fiber diameter (nano-1 (390 nm)
ISSN:	0142-9612 1878-5905
DOI:	10.1016/j.biomaterials.2016.10.013