Coordinated Tumor Suppression by Chromosome 8p

In this issue of Cancer Cell, Cai et al. use genome editing to study 8p deletions in a mammary epithelial cell model and show that 8p loss of heterozygosity (LOH) attenuates the action of several genes that collectively promote cell invasion and enhance cellular sensitivity to autophagy inhibitors. In this issue of Cancer Cell, Cai et al. use genome editing to study 8p deletions in a mammary epithelial cell model and show that that 8p LOH attenuates the action of several genes that collectively promote cell invasion and enhance cellular sensitivity to autophagy inhibitors.