Inducible HGF-secreting Human Umbilical Cord Blood-derived MSCs Produced via TALEN-mediated Genome Editing Promoted Angiogenesis

Inducible HGF-secreting Human Umbilical Cord Blood-derived MSCs Produced via TALEN-mediated Genome Editing Promoted Angiogenesis

Mesenchymal stem cells (MSCs) promote therapeutic angiogenesis to cure serious vascular disorders. However, their survival period and cytokine-secretory capacity are limited. Although hepatocyte growth factor (HGF) can accelerate the rate of angiogenesis, recombinant HGF is limited because of its ve...

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Veröffentlicht in:Molecular therapy 2016-09, Vol.24 (9), p.1644-1654
Hauptverfasser: Chang, Hyun-Kyung, Kim, Pyung-Hwan, Cho, Hyun-Min, Yum, Soo-Young, Choi, Young-Jin, Son, YeonSung, Lee, DaBin, Kang, InSung, Kang, Kyung-Sun, Jang, Goo, Cho, Je-Yoel
Format: Artikel
Sprache:eng
Schlagworte:
Angiogenesis
Biochemistry
Cell growth
Chromosomes
Efficiency
Genomes
Growth factors
Ischemia
Original
Science
Smooth muscle
Stem cells
Umbilical cord
Veterinary colleges
Veterinary medicine
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Zusammenfassung:Mesenchymal stem cells (MSCs) promote therapeutic angiogenesis to cure serious vascular disorders. However, their survival period and cytokine-secretory capacity are limited. Although hepatocyte growth factor (HGF) can accelerate the rate of angiogenesis, recombinant HGF is limited because of its very short half-life (
ISSN:1525-0016
1525-0024
DOI:10.1038/mt.2016.120