Variations in DNA methylation of interferon gamma and programmed death 1 in allograft rejection after kidney transplantation

Variations in DNA methylation of interferon gamma and programmed death 1 in allograft rejection after kidney transplantation

The role of DNA methylation in the regulation of the anti-donor-directed immune response after organ transplantation is unknown. Here, we studied the methylation of two mediators of the immune response: the pro-inflammatory cytokine ( ) and the inhibitory receptor ( ) in naïve and memory CD8+ T cell...

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Veröffentlicht in:Clinical epigenetics 2016-11, Vol.8 (1), p.116-116, Article 116
Hauptverfasser: Boer, Karin, de Wit, L Elly A, Peters, Fleur S, Hesselink, Dennis A, Hofland, Leo J, Betjes, Michiel G H, Looman, Caspar W N, Baan, Carla C
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
CD8-Positive T-Lymphocytes - metabolism
Complications and side effects
CpG Islands
DNA Methylation
Epigenesis, Genetic
Female
Gene expression
Genetic aspects
Genetic variation
Graft rejection
Graft Rejection - blood
Graft Rejection - genetics
Health aspects
Humans
Interferon-gamma - genetics
Interferon-gamma - metabolism
Kidney Transplantation
Male
Middle Aged
Programmed Cell Death 1 Receptor - genetics
Programmed Cell Death 1 Receptor - metabolism
Risk factors
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Zusammenfassung:The role of DNA methylation in the regulation of the anti-donor-directed immune response after organ transplantation is unknown. Here, we studied the methylation of two mediators of the immune response: the pro-inflammatory cytokine ( ) and the inhibitory receptor ( ) in naïve and memory CD8+ T cell subsets in kidney transplant recipients receiving immunosuppressive medication. Both recipients experiencing an episode of acute allograft rejection (rejectors) as well as recipients without rejection (non-rejectors) were included. CpGs in the promoter regions of both and were significantly (  
ISSN:1868-7075
1868-7083
1868-7083
1868-7075
DOI:10.1186/s13148-016-0288-0