Imaging mass spectrometry assists in the classification of diagnostically challenging atypical Spitzoid neoplasms

Background Previously, using imaging mass spectrometry (IMS), we discovered proteomic differences between Spitz nevi and Spitzoid melanomas. Objective We sought to determine whether IMS can assist in the classification of diagnostically challenging atypical Spitzoid neoplasms (ASN), to compare and c...

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Veröffentlicht in:	Journal of the American Academy of Dermatology 2016-12, Vol.75 (6), p.1176-1186.e4
Hauptverfasser:	Lazova, Rossitza, MD, Seeley, Erin H., PhD, Kutzner, Heinz, MD, Scolyer, Richard A., MD, Scott, Glynis, MD, Cerroni, Lorenzo, MD, Fried, Isabella, MD, Kozovska, Milena E., MD, Rosenberg, Arlene S., MD, Prieto, Victor G., MD, PhD, Shehata, Bahig M., MD, Durham, Megan M., MD, Henry, Gina, MD, Rodriguez-Peralto, Jose L., MD, Riveiro-Falkenbach, Erica, MD, Schaefer, Jochen T., MD, Danialan, Richard, MD, Fraitag, Sylvie, MD, Vollenweider-Roten, Sonja, MD, Sepehr, Alireza, MD, Sangueza, Martin, MD, Hijazi, Nouf, MD, Corredoira, Yamile, MD, Kowal, Rachel, MD, Harris, Olga M., MD, Bravo, Francisco, MD, Boyd, Alan S., MD, Gueorguieva, Ralitza, PhD, Caprioli, Richard M., PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Age Factors Aged Aged, 80 and over atypical Spitzoid neoplasm Child Child, Preschool Dermatology Diagnosis, Differential Female histopathology Humans imaging mass spectrometry Lymphatic Metastasis Male Mass Spectrometry Melanoma - chemistry Melanoma - diagnostic imaging Melanoma - secondary Middle Aged Neoplasm Recurrence, Local - chemistry Neoplasm Recurrence, Local - diagnostic imaging Neoplasm Recurrence, Local - pathology Nevus, Epithelioid and Spindle Cell - chemistry Nevus, Epithelioid and Spindle Cell - diagnostic imaging Nevus, Epithelioid and Spindle Cell - pathology Proteins - analysis Retrospective Studies Risk Assessment Sentinel Lymph Node Biopsy Skin Neoplasms - chemistry Skin Neoplasms - diagnostic imaging Skin Neoplasms - pathology Spitz nevus Spitzoid melanoma Treatment Outcome Tumor Burden Young Adult
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Zusammenfassung:	Background Previously, using imaging mass spectrometry (IMS), we discovered proteomic differences between Spitz nevi and Spitzoid melanomas. Objective We sought to determine whether IMS can assist in the classification of diagnostically challenging atypical Spitzoid neoplasms (ASN), to compare and correlate the IMS and histopathological diagnoses with clinical behavior. Methods We conducted a retrospective collaborative study involving centers from 11 countries and 11 US institutions analyzing 102 ASNs by IMS. Patients were divided into clinical groups 1 to 4 representing best to worst clinical behavior. The association among IMS findings, histopathological diagnoses, and clinical groups was assessed. Results There was a strong association between a diagnosis of Spitzoid melanoma by IMS and lesions categorized as clinical groups 2, 3, and 4 (recurrence of disease, metastases, or death) compared with clinical group 1 (no recurrence or metastasis beyond a sentinel node) ( P
ISSN:	0190-9622 1097-6787
DOI:	10.1016/j.jaad.2016.07.007