Nebraska Red: a phosphinate-based near-infrared fluorophore scaffold for chemical biology applications

A series of novel phosphinate-based dyes displaying near-infrared fluorescence (NIR) are reported. These dyes exhibit remarkable photostability and brightness. The phosphinate functionality is leveraged as an additional reactive handle in order to tune cell permeability as well as provide a proof-of...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2016-01, Vol.52 (83), p.12290-12293
Hauptverfasser:	Zhou, Xinqi, Lai, Rui, Beck, Jon R, Li, Hui, Stains, Cliff I
Format:	Artikel
Sprache:	eng
Schlagworte:	Biology Brightness Cell Membrane Permeability Chemical compounds Drug Delivery Systems Dyes Fluorescence Fluorescent Dyes - chemistry Handles HeLa Cells Humans Nanoparticles - chemistry Phosphinic Acids - chemistry Reactive Nitrogen Species - metabolism Reactive Oxygen Species - metabolism Scaffolds Spectroscopy, Near-Infrared - methods Vehicles
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Beschreibung
Zusammenfassung:	A series of novel phosphinate-based dyes displaying near-infrared fluorescence (NIR) are reported. These dyes exhibit remarkable photostability and brightness. The phosphinate functionality is leveraged as an additional reactive handle in order to tune cell permeability as well as provide a proof-of-principle for a self-reporting small molecule delivery vehicle.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c6cc05717a