High doses of granulocyte-macrophage colony stimulating factor inhibit antibody responses in rectal secretions and diminish MVA/SIV vaccine protection in TRIM5α restrictive macaques

High doses of granulocyte-macrophage colony stimulating factor inhibit antibody responses in rectal secretions and diminish MVA/SIV vaccine protection in TRIM5α restrictive macaques

Here, we test in rhesus macaques the effects of a 500-fold range of an admixed recombinant modified vaccinia Ankara (MVA) expressing rhesus GM-CSF (MVA/GM-CSF) on the immunogenicity and protection elicited by an MVA/simian immunodeficiency macaque 239 (SIVmac239) vaccine. High doses of the MVA/GM-CS...

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Veröffentlicht in:The Journal of immunology (1950) 2016-09, Vol.197 (9), p.3586-3596
Hauptverfasser: Kannanganat, Sunil, Wyatt, Linda S, Gangadhara, Sailaja, Chamcha, Venkateswarlu, Chea, Lynette S., Kozlowski, Pamela A, LaBranche, Celia C, Chennareddi, Lakshmi, Lawson, Benton, Reddy, Pradeep B. J., Styles, Tiffany M., Vanderford, Thomas H, Montefiori, David C, Moss, Bernard, Robinson, Harriet L, Amara, Rama Rao
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Sprache:eng
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Zusammenfassung:Here, we test in rhesus macaques the effects of a 500-fold range of an admixed recombinant modified vaccinia Ankara (MVA) expressing rhesus GM-CSF (MVA/GM-CSF) on the immunogenicity and protection elicited by an MVA/simian immunodeficiency macaque 239 (SIVmac239) vaccine. High doses of the MVA/GM-CSF did not affect the levels of systemic Env-specific Ab but did decrease the expression of the gut homing receptor α4β7 on plasmacytoid dendritic cells (p
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.1600629