Local Inhibition of Macrophage and Smooth Muscle Cell Proliferation to Suppress Plaque Progression

Atherosclerosis is a complex process responsible for a major burden of cardiovascular morbidity and mortality. Macrophages and smooth muscle cells (SMCs) are abundant within atherosclerotic plaques. This review discusses the role of macrophages and SMCs in plaque progression and provides an overview...

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Veröffentlicht in:	Methodist DeBakey cardiovascular journal 2016-09, Vol.12 (3), p.141-145
Hauptverfasser:	Sukhovershin, Roman A, Toledano Furman, Naama E, Tasciotti, Ennio, Trachtenberg, Barry H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Proliferation Disease Progression Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Macrophages - drug effects Macrophages - pathology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - pathology Nanotherapeutics for Vascular Disease Plaque, Atherosclerotic - pathology Plaque, Atherosclerotic - prevention & control
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Beschreibung
Zusammenfassung:	Atherosclerosis is a complex process responsible for a major burden of cardiovascular morbidity and mortality. Macrophages and smooth muscle cells (SMCs) are abundant within atherosclerotic plaques. This review discusses the role of macrophages and SMCs in plaque progression and provides an overview of nanoparticle-based approaches and other current methods for local targeting of atherosclerotic plaques.
ISSN:	1947-6094 1947-6108
DOI:	10.14797/mdcj-12-3-141