β-Catenin Expression Negatively Correlates with WIF1 and Predicts Poor Clinical Outcomes in Patients with Cervical Cancer

Aberrant activation of the canonical Wnt pathway plays a significant role in cervical cancer (CC). However, limited data show the correlation between the cancer clinicopathological characteristics and the key molecules such as β-catenin and Wnt inhibitory factor 1 (WIF1). In this study, β-catenin an...

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Veröffentlicht in:BioMed research international 2016-01, Vol.2016 (2016), p.1-9
Hauptverfasser: Lin, Zhongqiu, Liu, Yunyun, Li, Ruixin, Xie, Xiaofei, Peng, Yongpai, Zhou, Hui, Liang, Jinxiao, Xie, Qingsheng
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Sprache:eng
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Zusammenfassung:Aberrant activation of the canonical Wnt pathway plays a significant role in cervical cancer (CC). However, limited data show the correlation between the cancer clinicopathological characteristics and the key molecules such as β-catenin and Wnt inhibitory factor 1 (WIF1). In this study, β-catenin and WIF1 expression were analyzed by immunohistochemistry for 196 patients with CC, 39 with cervical intraepithelial neoplasia (CIN), and 41 with normal cervical epithelium (NCE). Significant overexpression of β-catenin was detected in CC (67.9%) when compared to CIN (43.6%) or NCE (34.1%), p
ISSN:2314-6133
2314-6141
DOI:10.1155/2016/4923903