Alteration of microRNA expressions in the pons and medulla in rats after 3,3′-iminodipropionitrile administration

Although 3,3′-iminodipropionitrile (IDPN) is widely used as a neurotoxicant to cause axonopathy due to accumulation of neurofilaments in several rodent models, its mechanism of neurotoxicity has not been fully understood. In particular, no information regarding microRNA (miRNA) alteration associated...

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Veröffentlicht in:	Journal of Toxicologic Pathology 2016, Vol.29(4), pp.229-236
Hauptverfasser:	Ogata, Keiko, Kushida, Masahiko, Miyata, Kaori, Sumida, Kayo, Takeda, Shuji, Izawa, Takeshi, Kuwamura, Mitsuru, Yamate, Jyoji
Format:	Artikel
Sprache:	eng
Schlagworte:	3′-iminodipropionitrile (IDPN) Accumulation Animal models axonal swelling axonopathy DNA microarrays Gait Glial cells Immunohistochemistry Medulla oblongata microRNA MicroRNAs miRNA Neurofilaments Neuronal-glial interactions Neurotoxicity Original Polymerase chain reaction Pons Rats Reverse transcription Ribonucleic acid RNA Rodents Spinal cord Spools
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