Differential diagnosis of lung cancer, its metastasis and chronic obstructive pulmonary disease based on serum Vegf, Il-8 and MMP-9

Differential diagnosis of lung cancer, its metastasis and chronic obstructive pulmonary disease based on serum Vegf, Il-8 and MMP-9

Chronic obstructive pulmonary disease (COPD) patients are at higher risk of developing lung cancer and its metastasis, but no suitable biomarker has been reported for differential diagnosis of these patients. Levels of serum biomarkers (VEGF, IL-8, MMP-9 and MMP-2) were analyzed in these patients, w...

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Veröffentlicht in:Scientific reports 2016-11, Vol.6 (1), p.36065-36065, Article 36065
Hauptverfasser: Balla, Murali M. S., Desai, Sejal, Purwar, Pallavi, Kumar, Amit, Bhandarkar, Prashant, Shejul, Yogesh K., Pramesh, C. S., Laskar, S., Pandey, Badri N.
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Sprache:eng
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13/1
631/67/1612
692/53/2421
Accuracy
Aged
Aged, 80 and over
Biomarkers, Tumor - blood
Case-Control Studies
Chronic obstructive pulmonary disease
Diagnosis, Differential
Differential diagnosis
Female
Gelatinase A
Gelatinase B
Humanities and Social Sciences
Humans
Interleukin 8
Interleukin-8 - blood
Lung cancer
Lung diseases
Lung Neoplasms - blood
Lung Neoplasms - diagnosis
Lung Neoplasms - secondary
Male
Matrix Metalloproteinase 2 - blood
Matrix Metalloproteinase 9 - blood
Metastases
Metastasis
Middle Aged
multidisciplinary
Obstructive lung disease
Pulmonary Disease, Chronic Obstructive - blood
Pulmonary Disease, Chronic Obstructive - diagnosis
Science
Vascular endothelial growth factor
Vascular Endothelial Growth Factor A - blood
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Zusammenfassung:Chronic obstructive pulmonary disease (COPD) patients are at higher risk of developing lung cancer and its metastasis, but no suitable biomarker has been reported for differential diagnosis of these patients. Levels of serum biomarkers (VEGF, IL-8, MMP-9 and MMP-2) were analyzed in these patients, which were compared with healthy donors (HD). Levels of VEGF (P 
ISSN:2045-2322
2045-2322
DOI:10.1038/srep36065