A pharmacological mouse model suggests a novel risk pathway for postpartum psychosis
Highlights • Postpartum psychosis (PP) is a severe psychiatric disorder of unknown cause. • Steroid sulfatase (STS) deficiency may influence PP risk. • Postpartum inhibition of STS in mice results in behavioural and genetic abnormalities. • These abnormalities can be alleviated with an antipsychotic...
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| Veröffentlicht in: | Psychoneuroendocrinology 2016-12, Vol.74, p.363-370 |
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| creator | Humby, Trevor Cross, Ellen S Messer, Lauren Guerrero, Silvia Davies, William, Dr |
| description | Highlights • Postpartum psychosis (PP) is a severe psychiatric disorder of unknown cause. • Steroid sulfatase (STS) deficiency may influence PP risk. • Postpartum inhibition of STS in mice results in behavioural and genetic abnormalities. • These abnormalities can be alleviated with an antipsychotic drug. • The study suggests a new mouse model and a biological risk pathway for PP. |
| doi_str_mv | 10.1016/j.psyneuen.2016.09.019 |
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Cross, Ellen S ; Messer, Lauren ; Guerrero, Silvia ; Davies, William, Dr</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-751139a9355b63a6751cf21571561078de33b1f505e987d9a43ae7a92e5372b13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>667-COUMATE</topic><topic>Animals</topic><topic>Antipsychotic Agents - administration & dosage</topic><topic>Antipsychotic Agents - pharmacology</topic><topic>Behavior, Animal - drug effects</topic><topic>Coumarins - administration & dosage</topic><topic>Coumarins - pharmacology</topic><topic>Disease Models, Animal</topic><topic>Elevated plus maze</topic><topic>Endocrinology & Metabolism</topic><topic>Female</topic><topic>Gene Expression - drug effects</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Nephroblastoma-overexpressed</topic><topic>Piperazines - administration & dosage</topic><topic>Piperazines - pharmacology</topic><topic>Psychiatry</topic><topic>Psychotic Disorders - drug therapy</topic><topic>Psychotic Disorders - etiology</topic><topic>Psychotic Disorders - metabolism</topic><topic>Puerperal Disorders - drug therapy</topic><topic>Puerperal Disorders - etiology</topic><topic>Puerperal Disorders - metabolism</topic><topic>Startle response</topic><topic>Steroid sulfatase</topic><topic>Steryl-Sulfatase - antagonists & inhibitors</topic><topic>Steryl-Sulfatase - metabolism</topic><topic>Sulfonamides - administration & dosage</topic><topic>Sulfonamides - pharmacology</topic><topic>Thiazoles - administration & dosage</topic><topic>Thiazoles - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Humby, Trevor</creatorcontrib><creatorcontrib>Cross, Ellen S</creatorcontrib><creatorcontrib>Messer, Lauren</creatorcontrib><creatorcontrib>Guerrero, Silvia</creatorcontrib><creatorcontrib>Davies, William, Dr</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Psychoneuroendocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Humby, Trevor</au><au>Cross, Ellen S</au><au>Messer, Lauren</au><au>Guerrero, Silvia</au><au>Davies, William, Dr</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A pharmacological mouse model suggests a novel risk pathway for postpartum psychosis</atitle><jtitle>Psychoneuroendocrinology</jtitle><addtitle>Psychoneuroendocrinology</addtitle><date>2016-12-01</date><risdate>2016</risdate><volume>74</volume><spage>363</spage><epage>370</epage><pages>363-370</pages><issn>0306-4530</issn><eissn>1873-3360</eissn><abstract>Highlights • Postpartum psychosis (PP) is a severe psychiatric disorder of unknown cause. • Steroid sulfatase (STS) deficiency may influence PP risk. • Postpartum inhibition of STS in mice results in behavioural and genetic abnormalities. • These abnormalities can be alleviated with an antipsychotic drug. • The study suggests a new mouse model and a biological risk pathway for PP.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>27728876</pmid><doi>10.1016/j.psyneuen.2016.09.019</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-1840-1799</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | 667-COUMATE Animals Antipsychotic Agents - administration & dosage Antipsychotic Agents - pharmacology Behavior, Animal - drug effects Coumarins - administration & dosage Coumarins - pharmacology Disease Models, Animal Elevated plus maze Endocrinology & Metabolism Female Gene Expression - drug effects Mice Mice, Inbred C57BL Nephroblastoma-overexpressed Piperazines - administration & dosage Piperazines - pharmacology Psychiatry Psychotic Disorders - drug therapy Psychotic Disorders - etiology Psychotic Disorders - metabolism Puerperal Disorders - drug therapy Puerperal Disorders - etiology Puerperal Disorders - metabolism Startle response Steroid sulfatase Steryl-Sulfatase - antagonists & inhibitors Steryl-Sulfatase - metabolism Sulfonamides - administration & dosage Sulfonamides - pharmacology Thiazoles - administration & dosage Thiazoles - pharmacology |
| title | A pharmacological mouse model suggests a novel risk pathway for postpartum psychosis |
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