A pharmacological mouse model suggests a novel risk pathway for postpartum psychosis

Highlights • Postpartum psychosis (PP) is a severe psychiatric disorder of unknown cause. • Steroid sulfatase (STS) deficiency may influence PP risk. • Postpartum inhibition of STS in mice results in behavioural and genetic abnormalities. • These abnormalities can be alleviated with an antipsychotic drug. • The study suggests a new mouse model and a biological risk pathway for PP.