V(D)J Recombination: Mechanism, Errors, and Fidelity

V(D)J Recombination: Mechanism, Errors, and Fidelity

V(D)J recombination, the mechanism responsible for generating antigen receptor diversity, has the potential to generate aberrant DNA rearrangements in developing lymphocytes. Indeed, the recombinase has been implicated in several different kinds of errors leading to oncogenic transformation. Here we...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Microbiology spectrum 2014-12, Vol.2 (6)
1. Verfasser: Roth, David B
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Genetic Variation
Humans
Receptors, Antigen
Receptors, Antigen - genetics
Review Article
V(D)J Recombination
VDJ Recombinases - metabolism
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:V(D)J recombination, the mechanism responsible for generating antigen receptor diversity, has the potential to generate aberrant DNA rearrangements in developing lymphocytes. Indeed, the recombinase has been implicated in several different kinds of errors leading to oncogenic transformation. Here we review the basic aspects of V(D)J recombination, mechanisms underlying aberrant DNA rearrangements, and the types of aberrant events uncovered in recent genomewide analyses of lymphoid neoplasms.
ISSN:2165-0497
2165-0497
DOI:10.1128/microbiolspec.mdna3-0041-2014