Transcriptome Profiling of Patient-Specific Human iPSC-Cardiomyocytes Predicts Individual Drug Safety and Efficacy Responses In Vitro

Understanding individual susceptibility to drug-induced cardiotoxicity is key to improving patient safety and preventing drug attrition. Human induced pluripotent stem cells (hiPSCs) enable the study of pharmacological and toxicological responses in patient-specific cardiomyocytes (CMs) and may serv...

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Veröffentlicht in:	Cell stem cell 2016-09, Vol.19 (3), p.311-325
Hauptverfasser:	Matsa, Elena, Burridge, Paul W., Yu, Kun-Hsing, Ahrens, John H., Termglinchan, Vittavat, Wu, Haodi, Liu, Chun, Shukla, Praveen, Sayed, Nazish, Churko, Jared M., Shao, Ningyi, Woo, Nicole A., Chao, Alexander S., Gold, Joseph D., Karakikes, Ioannis, Snyder, Michael P., Wu, Joseph C.
Format:	Artikel
Sprache:	eng
Schlagworte:	cardiomyocytes Cell Death - drug effects CRISPR-Cas Systems - genetics Gene Editing Gene Expression Profiling Genome, Human Heart Ventricles - drug effects Heart Ventricles - metabolism Humans induced pluripotent stem cells Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - metabolism Inverted Repeat Sequences - genetics Myocytes, Cardiac - cytology Myocytes, Cardiac - metabolism personalized drug safety and efficacy precision medicine Rosiglitazone Tacrolimus - adverse effects Thiazolidinediones - adverse effects Treatment Outcome
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