Interplay of innate and adaptive immunity in metal-induced hypersensitivity

Highlights • Metal-induced hypersensitivity involves sensitization of metal-reactive T cells. • Metals penetrate skin and lung barriers and interact with self-proteins and cells. • Metals activate innate immune responses that may contribute to sensitization. • Metals interact with MHCII/peptide comp...

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Veröffentlicht in:	Current opinion in immunology 2016-10, Vol.42, p.25-30
Hauptverfasser:	McKee, Amy S, Fontenot, Andrew P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive Immunity Allergens - immunology Allergy and Immunology Animals Apoptosis Autoantigens - immunology Autoimmunity CD4-Positive T-Lymphocytes - immunology Histocompatibility Antigens Class II - metabolism Humans Hypersensitivity, Delayed - immunology Immunity, Innate Metals - immunology Protein Binding Receptors, Pattern Recognition - metabolism
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Beschreibung
Zusammenfassung:	Highlights • Metal-induced hypersensitivity involves sensitization of metal-reactive T cells. • Metals penetrate skin and lung barriers and interact with self-proteins and cells. • Metals activate innate immune responses that may contribute to sensitization. • Metals interact with MHCII/peptide complexes to activate CD4+ T cells.
ISSN:	0952-7915 1879-0372
DOI:	10.1016/j.coi.2016.05.001