Synergistic cell death in FLT3-ITD positive acute myeloid leukemia by combined treatment with metformin and 6-benzylthioinosine

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Veröffentlicht in:	Leukemia research 2016-11, Vol.50, p.132-140
Hauptverfasser:	Sabnis, Himalee S, Bradley, Heath L, Tripathi, Shweta, Yu, Wen-Mei, Tse, William, Qu, Cheng-Kui, Bunting, Kevin D
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Combined Chemotherapy Protocols - therapeutic use Cancer metabolism Cell Death - drug effects Cell Line, Tumor Drug Synergism Fetal Blood - cytology fms-Like Tyrosine Kinase 3 - genetics fms-Like Tyrosine Kinase 3 - physiology Glycolysis Glycolysis - drug effects Hematology, Oncology and Palliative Medicine Humans Inverted Repeat Sequences Leukemia Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - genetics Metformin Metformin - therapeutic use Oxidative phosphorylation STAT5 Transcription Factor - antagonists & inhibitors Thioinosine - analogs & derivatives Thioinosine - therapeutic use
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