Copper-Catalyzed Amidation of Primary and Secondary Alkyl Boronic Esters

The oxidative copper‐catalyzed cross‐coupling of functionalized alkyl boronic esters with primary amides is reported. Through the identification of appropriate diketimine ligands, conditions for efficient coupling of both primary and secondary alkyl boronic esters with diverse primary amides, includ...

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Veröffentlicht in:Chemistry : a European journal 2016-10, Vol.22 (44), p.15654-15658
Hauptverfasser: Mori-Quiroz, Luis M., Shimkin, Kirk W., Rezazadeh, Sina, Kozlowski, Ryan A., Watson, Donald A.
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Sprache:eng
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Zusammenfassung:The oxidative copper‐catalyzed cross‐coupling of functionalized alkyl boronic esters with primary amides is reported. Through the identification of appropriate diketimine ligands, conditions for efficient coupling of both primary and secondary alkyl boronic esters with diverse primary amides, including acetamide, have been developed. NacNac time! The oxidative copper‐catalyzed cross‐coupling of functionalized alkyl boronic esters with primary amides is reported. Through the identification of appropriate diketimine ligands, conditions for efficient coupling of both primary and secondary alkyl boronic esters with diverse primary amides, including acetamide, have been developed (see scheme).
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201603677