Genetics of immune-mediated disorders: from genome-wide association to molecular mechanism

Genetics of immune-mediated disorders: from genome-wide association to molecular mechanism

Highlights • Majority of the SNPs associated with immune-mediated disease impact gene expression. • Growing evidence on shared genetics between infectious and immune-mediated diseases. • Several autoimmune SNPs are stimulation or condition specific eQTLs. • Integrative approaches are powerful post-G...

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Veröffentlicht in:Current opinion in immunology 2014-12, Vol.31, p.51-57
Hauptverfasser: Kumar, Vinod, Wijmenga, Cisca, Xavier, Ramnik J
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Animals
Genetic Variation
Genome-Wide Association Study
HLA Antigens - genetics
Humans
Immune System Diseases - genetics
Quantitative Trait Loci
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Zusammenfassung:Highlights • Majority of the SNPs associated with immune-mediated disease impact gene expression. • Growing evidence on shared genetics between infectious and immune-mediated diseases. • Several autoimmune SNPs are stimulation or condition specific eQTLs. • Integrative approaches are powerful post-GWAS strategies.
ISSN:0952-7915
1879-0372
DOI:10.1016/j.coi.2014.09.007