Wheel running reduces ethanol seeking by increasing neuronal activation and reducing oligodendroglial/neuroinflammatory factors in the medial prefrontal cortex

Highlights • Protracted abstinence enhances ethanol seeking triggered by contexual cues. • Enhanced ethanol seeking is associated with oligodendrogenesis and neuroinflammatory responses in the mPFC. • Wheel running during abstinence prevents ethanol seeking triggered by contexual cues. • Reduced see...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2016-11, Vol.58, p.357-368
Hauptverfasser:	Somkuwar, Sucharita S, Fannon, McKenzie J, Ghofranian, Atoosa, Quigley, Jacqueline A, Dutta, Rahul R, Galinato, Melissa H, Mandyam, Chitra D
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Allergy and Immunology Animals BrdU Cues Drug-Seeking Behavior Encephalitis - metabolism Ethanol - administration & dosage Extinction, Psychological - drug effects Male MBP Medial prefrontal cortex MOG Motor Activity - drug effects Neurons - drug effects Neurons - metabolism NG2 Olig2 Oligodendroglia - drug effects Oligodendroglia - metabolism PECAM-1 Platelet Endothelial Cell Adhesion Molecule-1 - metabolism Prefrontal Cortex - drug effects Prefrontal Cortex - metabolism Psychiatry Rats, Wistar Reinstatement Wheel running
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Zusammenfassung:	Highlights • Protracted abstinence enhances ethanol seeking triggered by contexual cues. • Enhanced ethanol seeking is associated with oligodendrogenesis and neuroinflammatory responses in the mPFC. • Wheel running during abstinence prevents ethanol seeking triggered by contexual cues. • Reduced seeking is associated with reduced oligodendrogenesis and neuroinflammatory responses in the mPFC.
ISSN:	0889-1591 1090-2139 1090-2139
DOI:	10.1016/j.bbi.2016.08.006