Increased irritability, anxiety, and immune reactivity in transgenic Huntington’s disease monkeys

Highlights • Huntington’s disease patients exhibit increased irritability, anxiety and inflammation. • Transgenic Huntington’s disease monkeys also express increased irritability and anxiety. • Huntington’s disease monkeys have high levels of cytokine in the periphery. • Huntington’s disease monkeys...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2016-11, Vol.58, p.181-190
Hauptverfasser:	Raper, Jessica, Bosinger, Steve, Johnson, Zachary, Tharp, Gregory, Moran, Sean, Chan, Anthony W.S
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggression Allergy and Immunology Animals Animals, Genetically Modified Anxiety Behavior, Animal C-Reactive Protein - metabolism Cytokines Disease Models, Animal Emotion Gene Expression Huntington Disease - genetics Huntington Disease - immunology Huntington Disease - psychology Hydrocortisone - blood IL-6 Inflammation Interleukin-6 - blood ISGs Leukocytes, Mononuclear - metabolism Macaca mulatta Male Psychiatry Stress, Physiological TNF-ɑ Tumor Necrosis Factor-alpha - blood
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Beschreibung
Zusammenfassung:	Highlights • Huntington’s disease patients exhibit increased irritability, anxiety and inflammation. • Transgenic Huntington’s disease monkeys also express increased irritability and anxiety. • Huntington’s disease monkeys have high levels of cytokine in the periphery. • Huntington’s disease monkeys have increased expression of immune pathway genes.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2016.07.004