β2 -adrenoceptors on tumor cells play a critical role in stress-enhanced metastasis in a mouse model of breast cancer

Highlights • β2-adrenoceptors on MDA-MB-231HM breast cancer cells contribute to stress-enhanced metastasis. • β2-adrenoceptor signaling regulates a shift to mesenchymal morphology in MDA-MB-231HM breast cancer cells. • Genetic modulation of β2-adrenoceptor on breast cancer cells regulates invasion....

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2016-10, Vol.57, p.106-115
Hauptverfasser:	Chang, Aeson, Le, Caroline P, Walker, Adam K, Creed, Sarah J, Pon, Cindy K, Albold, Sabine, Carroll, Dominic, Halls, Michelle L, Robert Lane, J, Riedel, Bernhard, Ferrari, Davide, Sloan, Erica K
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Breast cancer Breast Neoplasms - metabolism Cell Line, Tumor - metabolism Chronic stress Disease Models, Animal Female Gene Expression Humans Invasion Metastasis Mice Mice, Inbred BALB C Mice, Transgenic Neoplasm Metastasis Psychiatry Receptors, Adrenergic, beta-2 - metabolism Stress, Psychological - metabolism β2-Adrenoceptor
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Zusammenfassung:	Highlights • β2-adrenoceptors on MDA-MB-231HM breast cancer cells contribute to stress-enhanced metastasis. • β2-adrenoceptor signaling regulates a shift to mesenchymal morphology in MDA-MB-231HM breast cancer cells. • Genetic modulation of β2-adrenoceptor on breast cancer cells regulates invasion.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2016.06.011