Whole‐genome analysis of influenza A(H1N1)pdm09 viruses isolated in Uganda from 2009 to 2011

We report a whole‐genome analysis of 19 influenza A(H1N1)pdm09 isolates from four Ugandan hospitals between 2009 and 2011. The isolates differed from the vaccine strain A/California/07/2009 by three amino acid substitutions P100S, S220T, and I338V in the hemagglutinin and by two amino acid substitut...

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Veröffentlicht in:	Influenza and other respiratory viruses 2016-11, Vol.10 (6), p.486-492
Hauptverfasser:	Byarugaba, Denis K., Erima, Bernard, Millard, Monica, Kibuuka, Hannah, Lkwago, Luswa, Bwogi, Josephine, Mimbe, Derrick, Kiconco, Jocelyn B., Tugume, Titus, Mworozi, Edison A., Turner, Jasmine, Mckenzie, Pamela P., Webby, Richard R. J., Webster, Robert G., Foret, Charlotte, Ducatez, Mariette F., Coldren, Rodney, Wabwire‐Mangen, Fred, Krauss, Scott
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Amino Acid Substitution Amino acids Antigens Antigens, Viral Biological evolution Evolution Evolution, Molecular Exo-a-sialidase Genetic analysis Genetic distance Genome, Viral Genomes Health surveillance Hemagglutinin Glycoproteins, Influenza Virus - chemistry Hemagglutinin Glycoproteins, Influenza Virus - genetics Hemagglutinins Hospitals Humans Infectious diseases Influenza Influenza A Influenza A Virus, H1N1 Subtype - genetics Influenza A Virus, H1N1 Subtype - isolation & purification influenza A(H1N1)pdm09 Influenza, Human - epidemiology Influenza, Human - virology Life Sciences Mutation Neuraminidase - chemistry Neuraminidase - genetics Pandemics Phylogenetics Phylogeny Public health Respiratory diseases RNA, Viral - genetics Seasons Sequence Analysis, RNA Short Uganda Uganda - epidemiology Vaccines Viruses whole‐genome sequencing
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Zusammenfassung:	We report a whole‐genome analysis of 19 influenza A(H1N1)pdm09 isolates from four Ugandan hospitals between 2009 and 2011. The isolates differed from the vaccine strain A/California/07/2009 by three amino acid substitutions P100S, S220T, and I338V in the hemagglutinin and by two amino acid substitutions V106I and N248D in the neuraminidase proteins with consistent mutations in all gene segments distinguishing isolates from the 2009/2010 to 2010/2011 seasons. Phylogenetic analysis showed low genetic evolution, with genetic distances of 0%–1.3% and 0.1%–1.6% for HA and NA genes, respectively. The amino acid substitutions did not lead to antigenic differences from the reference strains.
ISSN:	1750-2640 1750-2659
DOI:	10.1111/irv.12401