ProNGF is a potential diagnostic biomarker for thyroid cancer

The precursor for nerve growth factor (proNGF) is expressed in some cancers but its clinicopathological significance is unclear. The present study aimed to define the clinicopathological significance of proNGF in thyroid cancer. ProNGF expression was analysed by immunohistochemistry in two cohorts o...

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Veröffentlicht in:	Oncotarget 2016-05, Vol.7 (19), p.28488-28497
Hauptverfasser:	Faulkner, Sam, Roselli, Severine, Demont, Yohann, Pundavela, Jay, Choquet, Genevieve, Leissner, Philippe, Oldmeadow, Christopher, Attia, John, Walker, Marjorie M, Hondermarck, Hubert
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma - diagnosis Adult Aged Area Under Curve Biomarkers, Tumor - analysis Carcinoma - diagnosis Female Humans Male Middle Aged Nerve Growth Factor - analysis Nerve Growth Factor - biosynthesis Protein Precursors - analysis Protein Precursors - biosynthesis Research Paper ROC Curve Sensitivity and Specificity Thyroid Neoplasms - diagnosis
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Zusammenfassung:	The precursor for nerve growth factor (proNGF) is expressed in some cancers but its clinicopathological significance is unclear. The present study aimed to define the clinicopathological significance of proNGF in thyroid cancer. ProNGF expression was analysed by immunohistochemistry in two cohorts of cancer versus benign tumors (adenoma) and normal thyroid tissues. In the first cohort (40 thyroid cancers, 40 thyroid adenomas and 80 normal thyroid tissues), proNGF was found overexpressed in cancers compared to adenomas and normal samples (p
ISSN:	1949-2553 1949-2553
DOI:	10.18632/oncotarget.8652