Distinct epigenetic signatures elucidate enhancer-gene relationships that delineate CIMP and non-CIMP colorectal cancers

Distinct epigenetic signatures elucidate enhancer-gene relationships that delineate CIMP and non-CIMP colorectal cancers

Epigenetic changes, like DNA methylation, affect gene expression and in colorectal cancer (CRC), a distinct phenotype called the CpG island methylator phenotype ("CIMP") has significantly higher levels of DNA methylation at so-called "Type C loci" within the genome. We postulate...

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Veröffentlicht in:Oncotarget 2016-05, Vol.7 (19), p.28027-28039
Hauptverfasser: Chong, Allen, Teo, Jing Xian, Ban, Kenneth H K
Format: Artikel
Sprache:eng
Schlagworte:
Cell Adhesion Molecules, Neuronal - genetics
Colorectal Neoplasms - genetics
CpG Islands - genetics
DNA Methylation - genetics
Enhancer Elements, Genetic - genetics
Epigenesis, Genetic
Gene Expression Regulation, Neoplastic - genetics
Humans
Immunoglobulins - genetics
Research Paper
Transcriptome
Wnt3A Protein - genetics
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Zusammenfassung:Epigenetic changes, like DNA methylation, affect gene expression and in colorectal cancer (CRC), a distinct phenotype called the CpG island methylator phenotype ("CIMP") has significantly higher levels of DNA methylation at so-called "Type C loci" within the genome. We postulate that enhancer-gene pairs are coordinately controlled through DNA methylation in order to regulate the expression of key genes/biomarkers for a particular phenotype.Firstly, we found 24 experimentally-validated enhancers (VISTA enhancer browser) that contained statistically significant (FDR-adjusted q-value of
ISSN:1949-2553
1949-2553
DOI:10.18632/oncotarget.8473