GRAND-4: the German retrospective analysis of long-term persistence in women with osteoporosis treated with bisphosphonates or denosumab

Summary This retrospective database study assessed 2-year persistence with bisphosphonates or denosumab in a large German cohort of women with a first-time prescription for osteoporosis treatment. Compared with intravenous or oral bisphosphonates, 2-year persistence was 1.5–2 times higher and risk o...

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Veröffentlicht in:	Osteoporosis international 2016-10, Vol.27 (10), p.2967-2978
Hauptverfasser:	Hadji, P., Kyvernitakis, I., Kann, P. H., Niedhart, C., Hofbauer, L. C., Schwarz, H., Kurth, A. A., Thomasius, F., Schulte, M., Intorcia, M., Psachoulia, E., Schmid, T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Bisphosphonates Bone Density Conservation Agents - therapeutic use Denosumab - therapeutic use Diphosphonates - therapeutic use Endocrinology Female Germany Humans Ibandronic acid Immunotherapy Intravenous administration Medication Adherence Medicine Medicine & Public Health Middle Aged Monoclonal antibodies Original Original Article Orthopedics Osteoporosis Osteoporosis, Postmenopausal - drug therapy Retrospective Studies Rheumatology Zoledronic acid
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Zusammenfassung:	Summary This retrospective database study assessed 2-year persistence with bisphosphonates or denosumab in a large German cohort of women with a first-time prescription for osteoporosis treatment. Compared with intravenous or oral bisphosphonates, 2-year persistence was 1.5–2 times higher and risk of discontinuation was significantly lower ( P
ISSN:	0937-941X 1433-2965
DOI:	10.1007/s00198-016-3623-6