Chronic fluoxetine dissociates contextual from auditory fear memory

•Fluoxetine treatment of adult mice impaired their contextual fear memory but spared auditory fear memory.•These data suggest that a blunting of hippocampal-mediated aversive memory may be a therapeutic action for this medication.•Hippocampal perineuronal net (PNN) density was not affected by fluoxe...

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Veröffentlicht in:Neuroscience letters 2016-10, Vol.632, p.152-156
Hauptverfasser: Sanders, Jeff, Mayford, Mark
Format: Artikel
Sprache:eng
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Zusammenfassung:•Fluoxetine treatment of adult mice impaired their contextual fear memory but spared auditory fear memory.•These data suggest that a blunting of hippocampal-mediated aversive memory may be a therapeutic action for this medication.•Hippocampal perineuronal net (PNN) density was not affected by fluoxetine. Fluoxetine is a medication used to treat Major Depressive Disorder and other psychiatric conditions. These experiments studied the effects of chronic fluoxetine treatment on the contextual versus auditory fear memory of mice. We found that chronic fluoxetine treatment of adult mice impaired their contextual fear memory, but spared auditory fear memory. Hippocampal perineuronal nets, which are involved in contextual fear memory plasticity, were unaltered by fluoxetine treatment. These data point to a selective inability to form contextual fear memory as a result of fluoxetine treatment, and they suggest that a blunting of hippocampal-mediated aversive memory may be a therapeutic action for this medication.
ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2016.08.057