Antibacterial activity of resazurin-based compounds against Neisseria gonorrhoeae in vitro and in vivo
Highlights • Resazurin is effective against Neisseria gonorrhoeae in vitro but not in vivo. • Serum albumin likely inactivates resazurin in vivo. • Resorufin pentyl ether (RPE) exhibits activity in the presence of serum albumin. • RPE reduces vaginal colonisation by N. gonorrhoeae over time. • Resaz...
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| Veröffentlicht in: | International journal of antimicrobial agents 2016-10, Vol.48 (4), p.367-372 |
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| container_title | International journal of antimicrobial agents |
| container_volume | 48 |
| creator | Schmitt, Deanna M Connolly, Kristie L Jerse, Ann E Detrick, Melinda S Horzempa, Joseph |
| description | Highlights • Resazurin is effective against Neisseria gonorrhoeae in vitro but not in vivo. • Serum albumin likely inactivates resazurin in vivo. • Resorufin pentyl ether (RPE) exhibits activity in the presence of serum albumin. • RPE reduces vaginal colonisation by N. gonorrhoeae over time. • Resazurin-based therapies could have potential for the treatment of gonorrhoea. |
| doi_str_mv | 10.1016/j.ijantimicag.2016.06.009 |
| format | Article |
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| ispartof | International journal of antimicrobial agents, 2016-10, Vol.48 (4), p.367-372 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Anti-Bacterial Agents - pharmacology Antibiotic Antimicrobial Cells, Cultured Disease Models, Animal Female Gonorrhea - drug therapy Gonorrhea - microbiology Gonorrhoea Humans Indicators and Reagents - pharmacology Infectious Disease Mice, Inbred BALB C Neisseria gonorrhoeae Neisseria gonorrhoeae - drug effects Neisseria gonorrhoeae - isolation & purification Oxazines - pharmacology Resazurin Resorufin Treatment Outcome Xanthenes - pharmacology |
| title | Antibacterial activity of resazurin-based compounds against Neisseria gonorrhoeae in vitro and in vivo |
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